{"title":"一项前瞻性队列研究，研究骨骼III类错颌的下颌后退伴或不伴上颌前移对睡眠相关呼吸参数的影响。","authors":"Ratanaporn Patharakorn, Nuntinee Nanthavanich Saengfai, Chaiyapol Chaweewannakorn, Supatchai Boonpratham, Yodhathai Satravaha, Supakit Peanchitlertkajorn","doi":"10.1007/s11325-025-03347-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate changes in sleep-related respiratory parameters before and after orthognathic surgery in patients with skeletal class III malocclusion.</p><p><strong>Methods: </strong>Adults with skeletal class III malocclusion and treated with isolated mandibular setback or bimaxillary surgery (maxillary advancement and mandibular setback) were recruited. Sleep-related respiratory parameters were obtained with type III sleep study. Epworth Sleepiness Scale (ESS) was also recorded. The pre- and post-operative (6 months) data were compared. Correlations between these changes and pre-operative characteristics were analyzed. Subjects were categorized into three groups based on changes in the respiratory event index (REI) and 3% oxygen desaturation index: Δ ≤ -2.5, -2.5 < Δ < 2.5, and Δ ≥ 2.5. Amounts of surgical movement and pre-surgical parameters were compared among the 3 groups.</p><p><strong>Results: </strong>Thirty patients with an average age of 25.4 ± 5.0 years were recruited. Eleven patients underwent isolated mandibular setbacks while nineteen received bimaxillary surgery. Pre- and post-operative sleep-related respiratory parameters were not significantly different in the total samples, and when analyzed separately according to surgical procedures. Pre-operative ESS were correlated with the changes in REI (p = 0.01), average blood oxygen levels (p = 0.01), and snoring percentage (p = 0.04). Additionally, this study found that patients with a significant decrease in REI (ΔREI ≤ -2.5) after surgery had significantly higher pre-operative REI (6.2 events/hour) compared to those with minor REI changes (2.6 events/hour).</p><p><strong>Conclusion: </strong>There was no significant change in sleep-related respiratory parameters following mandibular setbacks with or without maxillary advancement in this study.</p><p><strong>Trail registered: </strong>This study was retrospectively registered and approved on February 11, 2025, under registration number TCTR20250211002.</p>","PeriodicalId":21862,"journal":{"name":"Sleep and Breathing","volume":"29 2","pages":"174"},"PeriodicalIF":2.0000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043792/pdf/","citationCount":"0","resultStr":"{\"title\":\"A prospective cohort study on effects of mandibular setback with or without maxillary advancement for skeletal class III malocclusion on sleep-related respiratory parameters.\",\"authors\":\"Ratanaporn Patharakorn, Nuntinee Nanthavanich Saengfai, Chaiyapol Chaweewannakorn, Supatchai Boonpratham, Yodhathai Satravaha, Supakit Peanchitlertkajorn\",\"doi\":\"10.1007/s11325-025-03347-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study aimed to investigate changes in sleep-related respiratory parameters before and after orthognathic surgery in patients with skeletal class III malocclusion.</p><p><strong>Methods: </strong>Adults with skeletal class III malocclusion and treated with isolated mandibular setback or bimaxillary surgery (maxillary advancement and mandibular setback) were recruited. Sleep-related respiratory parameters were obtained with type III sleep study. Epworth Sleepiness Scale (ESS) was also recorded. The pre- and post-operative (6 months) data were compared. Correlations between these changes and pre-operative characteristics were analyzed. Subjects were categorized into three groups based on changes in the respiratory event index (REI) and 3% oxygen desaturation index: Δ ≤ -2.5, -2.5 < Δ < 2.5, and Δ ≥ 2.5. Amounts of surgical movement and pre-surgical parameters were compared among the 3 groups.</p><p><strong>Results: </strong>Thirty patients with an average age of 25.4 ± 5.0 years were recruited. Eleven patients underwent isolated mandibular setbacks while nineteen received bimaxillary surgery. Pre- and post-operative sleep-related respiratory parameters were not significantly different in the total samples, and when analyzed separately according to surgical procedures. Pre-operative ESS were correlated with the changes in REI (p = 0.01), average blood oxygen levels (p = 0.01), and snoring percentage (p = 0.04). Additionally, this study found that patients with a significant decrease in REI (ΔREI ≤ -2.5) after surgery had significantly higher pre-operative REI (6.2 events/hour) compared to those with minor REI changes (2.6 events/hour).</p><p><strong>Conclusion: </strong>There was no significant change in sleep-related respiratory parameters following mandibular setbacks with or without maxillary advancement in this study.</p><p><strong>Trail registered: </strong>This study was retrospectively registered and approved on February 11, 2025, under registration number TCTR20250211002.</p>\",\"PeriodicalId\":21862,\"journal\":{\"name\":\"Sleep and Breathing\",\"volume\":\"29 2\",\"pages\":\"174\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-04-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043792/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sleep and Breathing\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s11325-025-03347-7\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sleep and Breathing","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11325-025-03347-7","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
A prospective cohort study on effects of mandibular setback with or without maxillary advancement for skeletal class III malocclusion on sleep-related respiratory parameters.
Purpose: This study aimed to investigate changes in sleep-related respiratory parameters before and after orthognathic surgery in patients with skeletal class III malocclusion.
Methods: Adults with skeletal class III malocclusion and treated with isolated mandibular setback or bimaxillary surgery (maxillary advancement and mandibular setback) were recruited. Sleep-related respiratory parameters were obtained with type III sleep study. Epworth Sleepiness Scale (ESS) was also recorded. The pre- and post-operative (6 months) data were compared. Correlations between these changes and pre-operative characteristics were analyzed. Subjects were categorized into three groups based on changes in the respiratory event index (REI) and 3% oxygen desaturation index: Δ ≤ -2.5, -2.5 < Δ < 2.5, and Δ ≥ 2.5. Amounts of surgical movement and pre-surgical parameters were compared among the 3 groups.
Results: Thirty patients with an average age of 25.4 ± 5.0 years were recruited. Eleven patients underwent isolated mandibular setbacks while nineteen received bimaxillary surgery. Pre- and post-operative sleep-related respiratory parameters were not significantly different in the total samples, and when analyzed separately according to surgical procedures. Pre-operative ESS were correlated with the changes in REI (p = 0.01), average blood oxygen levels (p = 0.01), and snoring percentage (p = 0.04). Additionally, this study found that patients with a significant decrease in REI (ΔREI ≤ -2.5) after surgery had significantly higher pre-operative REI (6.2 events/hour) compared to those with minor REI changes (2.6 events/hour).
Conclusion: There was no significant change in sleep-related respiratory parameters following mandibular setbacks with or without maxillary advancement in this study.
Trail registered: This study was retrospectively registered and approved on February 11, 2025, under registration number TCTR20250211002.
期刊介绍：
The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep.
Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.
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