Cannabis Use Trajectories Among People Living With HIV in the Decade Prior to Recreational Legalization in Ontario, Canada (2008-2017).

We aimed to describe long-term use trajectories and predictors prior to recreational cannabis legalization in people with HIV in Ontario, Canada. We analysed interview data from the prospective Ontario HIV Treatment Network Cohort Study from 2008 to 2017. We conducted Latent Class Growth Analyses to describe cannabis use trajectories and chi-square tests to identify trajectory group predictors. Most participants (N = 3,299) were male (81%), gay (57%), current/former tobacco smokers (58%), and many had significant symptoms of depression (43%). Four cannabis use trajectory groups were identified (Low/No Use (67%); Increased Use (4%); Decreased use (2%); High Use (26%)). Relative to the Low/No Use group, membership in the High Use group was associated with several predictors such as being older age, completing university, smoking tobacco, and significant depressive symptoms. Future research should explore the relationship between cannabis use and depressive symptoms, outcomes associated with trajectory groups and changes in use trajectories following recreational legalization.