Rachel C Whooten, Sheryl L Rifas-Shiman, Wei Perng, Jorge E Chavarro, Emily Oken, Marie-France Hivert
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In multivariable logistic regression models, we adjusted for maternal education and PCOS, child race and ethnicity, and child health behaviors.</p><p><strong>Results: </strong>Among 341 female adolescents, n = 47 (14%) met criteria for PCOS in late adolescence. In early adolescence (∼13 years old), mean (SD) BMIz was 0.32 (1.10) units and mean (SD) MVPA was 27.1 (17.9) min/day. After adjusting for covariates, early adolescent BMIz was associated with later PCOS (OR=1.72 95% CI = 1.15, 2.56 per unit increase in BMIz). In stratified analyses, the association of early adolescent BMIz with later PCOS was apparent for those in the lowest tertile of MVPA (OR 3.22; 95% CI 1.25, 8.31) however was weaker among those more active (MVPA tertile 2 OR = 1.65; 95% CI 0.74, 3.67 and tertile 3 OR = 1.34; 95% CI = 0.63, 2.86, respectively).The interaction term p-value was non-significant (P = .36).</p><p><strong>Conclusion: </strong>Our findings suggest that the detrimental effect of adiposity in relation to PCOS risk is most apparent only among those with lower MVPA. Maintaining adequate MVPA during the early teen years may mitigate PCOS risk associated with excess adiposity.</p>","PeriodicalId":16708,"journal":{"name":"Journal of pediatric and adolescent gynecology","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Physical Activity May Attenuate the Association of Early Adolescent Adiposity With PCOS Assessed in Later Adolescence: Findings From a Prospective Cohort, Project Viva.\",\"authors\":\"Rachel C Whooten, Sheryl L Rifas-Shiman, Wei Perng, Jorge E Chavarro, Emily Oken, Marie-France Hivert\",\"doi\":\"10.1016/j.jpag.2025.04.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To assess how moderate-vigorous physical activity (MVPA) may modify the association of early adolescent adiposity with late adolescent polycystic ovary syndrome (PCOS).</p><p><strong>Methods: </strong>Within the Project Viva prospective cohort, we assessed the association of body mass index z-score (BMIz) at early adolescence (mean age 13.1 years) with later PCOS (self-reported diagnosis or oligo-anovulation with clinical/biochemical hyperandrogenism) at mean age 17.7 years. We stratified our analyses by tertile of actigraphy-assessed moderate-vigorous physical activity (MVPA) during early adolescence . In multivariable logistic regression models, we adjusted for maternal education and PCOS, child race and ethnicity, and child health behaviors.</p><p><strong>Results: </strong>Among 341 female adolescents, n = 47 (14%) met criteria for PCOS in late adolescence. In early adolescence (∼13 years old), mean (SD) BMIz was 0.32 (1.10) units and mean (SD) MVPA was 27.1 (17.9) min/day. After adjusting for covariates, early adolescent BMIz was associated with later PCOS (OR=1.72 95% CI = 1.15, 2.56 per unit increase in BMIz). In stratified analyses, the association of early adolescent BMIz with later PCOS was apparent for those in the lowest tertile of MVPA (OR 3.22; 95% CI 1.25, 8.31) however was weaker among those more active (MVPA tertile 2 OR = 1.65; 95% CI 0.74, 3.67 and tertile 3 OR = 1.34; 95% CI = 0.63, 2.86, respectively).The interaction term p-value was non-significant (P = .36).</p><p><strong>Conclusion: </strong>Our findings suggest that the detrimental effect of adiposity in relation to PCOS risk is most apparent only among those with lower MVPA. 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引用次数: 0
摘要
目的:探讨中度剧烈运动(MVPA)对青少年早期肥胖与晚期多囊卵巢综合征(PCOS)的影响。方法:在Viva项目前瞻性队列中,我们评估了青春期早期(平均年龄13.1岁)的体重指数z分数(bmi)与后期PCOS(自我报告诊断或少排卵伴临床/生化高雄激素症)平均年龄17.7岁的相关性。我们通过活动记录仪评估的青少年早期中度剧烈身体活动(MVPA)的分位数对分析进行分层。在多变量logistic回归模型中,我们调整了母亲教育程度和多囊卵巢综合征、儿童种族和民族以及儿童健康行为。结果:341名女性青少年中,47名(14%)在青春期晚期符合PCOS标准。在青春期早期(~ 13岁),平均(SD) BMIz为0.32(1.10)个单位,平均(SD) MVPA为27.1(17.9)分钟/天。在调整协变量后,早期青少年BMIz与后期PCOS相关(OR=1.72 95%CI=1.15,每单位BMIz增加2.56)。在分层分析中,青春期早期BMIz与后期PCOS的关联在MVPA最低分位数(OR 3.22;95% CI 1.25, 8.31),但在更活跃的人群中较弱(MVPA tertile 2 OR = 1.65;95%置信区间为0.74,3.67,三分位数OR=1.34;95% CI分别=0.63,2.86)。交互作用项p值不显著(p=0.36)。结论:我们的研究结果表明,肥胖对PCOS风险的有害影响仅在MVPA较低的人群中最为明显。在青少年早期维持足够的MVPA可以减轻与过度肥胖相关的PCOS风险。
Physical Activity May Attenuate the Association of Early Adolescent Adiposity With PCOS Assessed in Later Adolescence: Findings From a Prospective Cohort, Project Viva.
Objective: To assess how moderate-vigorous physical activity (MVPA) may modify the association of early adolescent adiposity with late adolescent polycystic ovary syndrome (PCOS).
Methods: Within the Project Viva prospective cohort, we assessed the association of body mass index z-score (BMIz) at early adolescence (mean age 13.1 years) with later PCOS (self-reported diagnosis or oligo-anovulation with clinical/biochemical hyperandrogenism) at mean age 17.7 years. We stratified our analyses by tertile of actigraphy-assessed moderate-vigorous physical activity (MVPA) during early adolescence . In multivariable logistic regression models, we adjusted for maternal education and PCOS, child race and ethnicity, and child health behaviors.
Results: Among 341 female adolescents, n = 47 (14%) met criteria for PCOS in late adolescence. In early adolescence (∼13 years old), mean (SD) BMIz was 0.32 (1.10) units and mean (SD) MVPA was 27.1 (17.9) min/day. After adjusting for covariates, early adolescent BMIz was associated with later PCOS (OR=1.72 95% CI = 1.15, 2.56 per unit increase in BMIz). In stratified analyses, the association of early adolescent BMIz with later PCOS was apparent for those in the lowest tertile of MVPA (OR 3.22; 95% CI 1.25, 8.31) however was weaker among those more active (MVPA tertile 2 OR = 1.65; 95% CI 0.74, 3.67 and tertile 3 OR = 1.34; 95% CI = 0.63, 2.86, respectively).The interaction term p-value was non-significant (P = .36).
Conclusion: Our findings suggest that the detrimental effect of adiposity in relation to PCOS risk is most apparent only among those with lower MVPA. Maintaining adequate MVPA during the early teen years may mitigate PCOS risk associated with excess adiposity.
期刊介绍:
Journal of Pediatric and Adolescent Gynecology includes all aspects of clinical and basic science research in pediatric and adolescent gynecology. The Journal draws on expertise from a variety of disciplines including pediatrics, obstetrics and gynecology, reproduction and gynecology, reproductive and pediatric endocrinology, genetics, and molecular biology.
The Journal of Pediatric and Adolescent Gynecology features original studies, review articles, book and literature reviews, letters to the editor, and communications in brief. It is an essential resource for the libraries of OB/GYN specialists, as well as pediatricians and primary care physicians.