与肠外营养不同输注方式相关的不良事件的变化:一项药物警戒研究。

IF 3.2 3区 医学 Q2 NUTRITION & DIETETICS
Zhou Jing, Jiang Zhengli, Su Ying, Man Shiyu, Ma Jingjing, Pang Mujuan, Xu Hongyan, Hu Yan
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引用次数: 0

摘要

背景:肠外营养可以通过多种输注方式进行。然而,有限的研究已经检查了与这些模式相关的不良反应的差异。方法:使用歧化分析对来自美国食品药品监督管理局不良事件报告系统数据库的数据进行分析,以识别和比较不同输液方式的不良事件信号。结果:共纳入与肠外营养相关的不良事件报告1642例,其中全合一组356例,二合一组85例,脂肪乳组1086例,氨基酸补充组115例。在所有报告中,确定了4159个首选术语,分布如下:全合一组858个,二合一组152个,脂肪乳组2975个,氨基酸补充组174个,这些事件跨越20个系统器官类别。在全合一组中,首选的前3个词是淋巴管炎、血镁增高、给药不正确率。在二合一组中,首选的主要术语是真菌血症、外渗和疾病并发症。在脂肪乳剂组,最显著的首选术语包括脂肪超载综合征、脂肪酸缺乏和肠外营养相关肝病。在氨基酸补充组中,首选的关键术语是葡萄糖耐量受损、高血糖和肝酶升高。结论:本研究确定了与不同肠外营养输注方式相关的不良事件的显著差异。这些发现强调需要量身定制的干预措施,以确保安全有效地使用肠外营养,从而优化临床实践中的治疗结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Variations in adverse events associated with different infusion modalities of parenteral nutrition: A pharmacovigilance study.

Background: Parenteral nutrition can be administered through various infusion modalities. However, limited research has examined the differences in adverse reactions associated with these modalities.

Methods: Data from the Food and Drug Administration adverse event reporting system database were analyzed using disproportionality analysis to identify and compare adverse event signals across different infusion modalities.

Results: A total of 1642 adverse event reports related to parenteral nutrition were included: 356 in the all-in-one group, 85 in the two-in-one group, 1086 in the fat emulsion group, and 115 in the amino acid supplementation group. Across all reports, 4159 preferred terms were identified, distributed as follows: 858 in the all-in-one group, 152 in the two-in-one group, 2975 in the fat emulsion group, and 174 in the amino acid supplementation group, with these events spanning 20 system organ classes. In the all-in-one group, the top three preferred terms were lymphangitis, increased blood magnesium, and incorrect drug administration rate. In the two-in-one group, the leading preferred terms were fungemia, extravasation, and disease complications. In the fat emulsion group, the most significant preferred terms included fat overload syndrome, fatty acid deficiency, and parenteral nutrition-associated liver disease. In the amino acid supplementation group, key preferred terms were impaired glucose tolerance, hyperglycemia, and elevated hepatic enzymes.

Conclusion: This study identified significant variations in the adverse events associated with different parenteral nutrition infusion modalities. These findings underscore the need for tailored interventions to ensure the safe and effective use of parenteral nutrition, thereby optimizing therapeutic outcomes in clinical practice.

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来源期刊
CiteScore
7.80
自引率
8.80%
发文量
161
审稿时长
6-12 weeks
期刊介绍: The Journal of Parenteral and Enteral Nutrition (JPEN) is the premier scientific journal of nutrition and metabolic support. It publishes original peer-reviewed studies that define the cutting edge of basic and clinical research in the field. It explores the science of optimizing the care of patients receiving enteral or IV therapies. Also included: reviews, techniques, brief reports, case reports, and abstracts.
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