Yanqin Zhu, Xueyan Zeng, Aiping Zhang, Bin Lu, Mengqi Wu, Hong Liu, Fenggui Zhu, Riyang Lin
{"title":"维持性血液透析患者舌苔厚度与微炎状态及口腔微生物群的相关性研究。","authors":"Yanqin Zhu, Xueyan Zeng, Aiping Zhang, Bin Lu, Mengqi Wu, Hong Liu, Fenggui Zhu, Riyang Lin","doi":"10.1080/20002297.2025.2488054","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>This study investigated the correlation between tongue coating thickness (TCT), micro-inflammatory state (MIS), and oral microbiome in maintenance hemodialysis (MHD) patients.</p><p><strong>Methods: </strong>Forty MHD patients (20 thin-tongue coating [BTZ], 20 thick-tongue coating [HTZ]) and 15 healthy controls (DZZ) were enrolled. Blood microinflammatory markers were analyzed in all patients. Saliva samples from 15 HTZ, 15 BTZ, and 15 DZZ underwent 16S rRNA sequencing.</p><p><strong>Results: </strong>HTZ patients exhibited higher microinflammatory marker levels than BTZ. Oral microbiome species richness in DZZ surpassed that of the MHD groups, with distinct structural differences, particularly between HTZ and DZZ. HTZ showed higher abundances of <i>Actinobacillus, Peptostreptococcus</i>, and Lachnospiraceae <i>NK4A136 group</i> than BTZ. Correlation analysis revealed a positive correlation between the levels of IL-6 and TNF-α and the abundance of <i>Fusobacterium</i>, but a negative correlation with <i>Streptococcus</i>. Additionally, the TNF-α level positively correlated with <i>Campylobacter</i>.</p><p><strong>Conclusion: </strong>Thick tongue coating in MHD patients is associated with elevated microinflammation and altered oral microbiome, suggesting a link between inflammation and microbial dysbiosis.</p>","PeriodicalId":16598,"journal":{"name":"Journal of Oral Microbiology","volume":"17 1","pages":"2488054"},"PeriodicalIF":3.7000,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054557/pdf/","citationCount":"0","resultStr":"{\"title\":\"Correlation of tongue coating thickness with microinflammatory state and oral microbiome in maintenance hemodialysis patients.\",\"authors\":\"Yanqin Zhu, Xueyan Zeng, Aiping Zhang, Bin Lu, Mengqi Wu, Hong Liu, Fenggui Zhu, Riyang Lin\",\"doi\":\"10.1080/20002297.2025.2488054\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>This study investigated the correlation between tongue coating thickness (TCT), micro-inflammatory state (MIS), and oral microbiome in maintenance hemodialysis (MHD) patients.</p><p><strong>Methods: </strong>Forty MHD patients (20 thin-tongue coating [BTZ], 20 thick-tongue coating [HTZ]) and 15 healthy controls (DZZ) were enrolled. Blood microinflammatory markers were analyzed in all patients. Saliva samples from 15 HTZ, 15 BTZ, and 15 DZZ underwent 16S rRNA sequencing.</p><p><strong>Results: </strong>HTZ patients exhibited higher microinflammatory marker levels than BTZ. Oral microbiome species richness in DZZ surpassed that of the MHD groups, with distinct structural differences, particularly between HTZ and DZZ. HTZ showed higher abundances of <i>Actinobacillus, Peptostreptococcus</i>, and Lachnospiraceae <i>NK4A136 group</i> than BTZ. Correlation analysis revealed a positive correlation between the levels of IL-6 and TNF-α and the abundance of <i>Fusobacterium</i>, but a negative correlation with <i>Streptococcus</i>. Additionally, the TNF-α level positively correlated with <i>Campylobacter</i>.</p><p><strong>Conclusion: </strong>Thick tongue coating in MHD patients is associated with elevated microinflammation and altered oral microbiome, suggesting a link between inflammation and microbial dysbiosis.</p>\",\"PeriodicalId\":16598,\"journal\":{\"name\":\"Journal of Oral Microbiology\",\"volume\":\"17 1\",\"pages\":\"2488054\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-05-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12054557/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Oral Microbiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/20002297.2025.2488054\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Oral Microbiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/20002297.2025.2488054","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Correlation of tongue coating thickness with microinflammatory state and oral microbiome in maintenance hemodialysis patients.
Aim: This study investigated the correlation between tongue coating thickness (TCT), micro-inflammatory state (MIS), and oral microbiome in maintenance hemodialysis (MHD) patients.
Methods: Forty MHD patients (20 thin-tongue coating [BTZ], 20 thick-tongue coating [HTZ]) and 15 healthy controls (DZZ) were enrolled. Blood microinflammatory markers were analyzed in all patients. Saliva samples from 15 HTZ, 15 BTZ, and 15 DZZ underwent 16S rRNA sequencing.
Results: HTZ patients exhibited higher microinflammatory marker levels than BTZ. Oral microbiome species richness in DZZ surpassed that of the MHD groups, with distinct structural differences, particularly between HTZ and DZZ. HTZ showed higher abundances of Actinobacillus, Peptostreptococcus, and Lachnospiraceae NK4A136 group than BTZ. Correlation analysis revealed a positive correlation between the levels of IL-6 and TNF-α and the abundance of Fusobacterium, but a negative correlation with Streptococcus. Additionally, the TNF-α level positively correlated with Campylobacter.
Conclusion: Thick tongue coating in MHD patients is associated with elevated microinflammation and altered oral microbiome, suggesting a link between inflammation and microbial dysbiosis.
期刊介绍：
As the first Open Access journal in its field, the Journal of Oral Microbiology aims to be an influential source of knowledge on the aetiological agents behind oral infectious diseases. The journal is an international forum for original research on all aspects of ''oral health''. Articles which seek to understand ''oral health'' through exploration of the pathogenesis, virulence, host-parasite interactions, and immunology of oral infections are of particular interest. However, the journal also welcomes work that addresses the global agenda of oral infectious diseases and articles that present new strategies for treatment and prevention or improvements to existing strategies.
Topics: ''oral health'', microbiome, genomics, host-pathogen interactions, oral infections, aetiologic agents, pathogenesis, molecular microbiology systemic diseases, ecology/environmental microbiology, treatment, diagnostics, epidemiology, basic oral microbiology, and taxonomy/systematics.
Article types: original articles, notes, review articles, mini-reviews and commentaries
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