{"title":"PET CT参数对HER-2阳性乳腺癌接受新辅助治疗患者病理反应的影响","authors":"Serhat Sekmek, Ozkan Bayrakcı, Mehmet Akif Karacan, Irfan Karahan, Sema Nur Ozsan Celebi, Didem Sener Dede, Efnan Algin, Berna Okudan, Oznur Bal, Serhat Sekmek","doi":"10.1159/000545820","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>We aimed to evaluate the relationship between positron emission tomography (PET)/computed tomography (CT) parameters with pathological complete response (pCR) in patients with HER-2-positive breast cancer who received neoadjuvant treatment (NACT).</p><p><strong>Methods: </strong>This retrospective study included 97 patients. The primary endpoint was pCR. ROC analysis was used to find the cut-off values of PET/CT parameters.</p><p><strong>Results: </strong>The median age of the patients was 50.8 (24.8-77.6) years. When the factors affecting the pCR of the patients after neoadjuvant treatment were analysed, it was observed that patients with low N stage (p = 0.046), patients with high lymph node (LN) metabolic tumour volume (MTV) value (p = 0.030) and high LN total lesion glycolysis (TLG) value (p = 0.014) had more pCR in their operation pathologies after NACT. Binary logistic regression analysis showed that both low N stage (hazard ratio [HR]: 0.073, 95% confidence interval [CI]: 0.016-0.332, p = 0.001) and high LN-TLG value (HR: 0.106, 95% CI: 0.016-0.727, p = 0.022) were independent risk factors affecting pCR. LN-MTV value was not statistically significant in regression analysis (p = 0.456).</p><p><strong>Conclusion: </strong>As a result of this retrospective study, it was observed that the group with high LN-TLG, one of the PET/CT parameters, had more pCR.</p>","PeriodicalId":19543,"journal":{"name":"Oncology Research and Treatment","volume":" ","pages":"407-413"},"PeriodicalIF":1.6000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Effect of Positron Emission Tomography-Computed Tomography Parameters on Pathological Response in Patients with Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Receiving Neoadjuvant Treatment.\",\"authors\":\"Serhat Sekmek, Ozkan Bayrakcı, Mehmet Akif Karacan, Irfan Karahan, Sema Nur Ozsan Celebi, Didem Sener Dede, Efnan Algin, Berna Okudan, Oznur Bal, Serhat Sekmek\",\"doi\":\"10.1159/000545820\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>We aimed to evaluate the relationship between positron emission tomography (PET)/computed tomography (CT) parameters with pathological complete response (pCR) in patients with HER-2-positive breast cancer who received neoadjuvant treatment (NACT).</p><p><strong>Methods: </strong>This retrospective study included 97 patients. The primary endpoint was pCR. ROC analysis was used to find the cut-off values of PET/CT parameters.</p><p><strong>Results: </strong>The median age of the patients was 50.8 (24.8-77.6) years. When the factors affecting the pCR of the patients after neoadjuvant treatment were analysed, it was observed that patients with low N stage (p = 0.046), patients with high lymph node (LN) metabolic tumour volume (MTV) value (p = 0.030) and high LN total lesion glycolysis (TLG) value (p = 0.014) had more pCR in their operation pathologies after NACT. Binary logistic regression analysis showed that both low N stage (hazard ratio [HR]: 0.073, 95% confidence interval [CI]: 0.016-0.332, p = 0.001) and high LN-TLG value (HR: 0.106, 95% CI: 0.016-0.727, p = 0.022) were independent risk factors affecting pCR. LN-MTV value was not statistically significant in regression analysis (p = 0.456).</p><p><strong>Conclusion: </strong>As a result of this retrospective study, it was observed that the group with high LN-TLG, one of the PET/CT parameters, had more pCR.</p>\",\"PeriodicalId\":19543,\"journal\":{\"name\":\"Oncology Research and Treatment\",\"volume\":\" \",\"pages\":\"407-413\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Oncology Research and Treatment\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000545820\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/10 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oncology Research and Treatment","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000545820","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/10 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
The Effect of Positron Emission Tomography-Computed Tomography Parameters on Pathological Response in Patients with Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Receiving Neoadjuvant Treatment.
Introduction: We aimed to evaluate the relationship between positron emission tomography (PET)/computed tomography (CT) parameters with pathological complete response (pCR) in patients with HER-2-positive breast cancer who received neoadjuvant treatment (NACT).
Methods: This retrospective study included 97 patients. The primary endpoint was pCR. ROC analysis was used to find the cut-off values of PET/CT parameters.
Results: The median age of the patients was 50.8 (24.8-77.6) years. When the factors affecting the pCR of the patients after neoadjuvant treatment were analysed, it was observed that patients with low N stage (p = 0.046), patients with high lymph node (LN) metabolic tumour volume (MTV) value (p = 0.030) and high LN total lesion glycolysis (TLG) value (p = 0.014) had more pCR in their operation pathologies after NACT. Binary logistic regression analysis showed that both low N stage (hazard ratio [HR]: 0.073, 95% confidence interval [CI]: 0.016-0.332, p = 0.001) and high LN-TLG value (HR: 0.106, 95% CI: 0.016-0.727, p = 0.022) were independent risk factors affecting pCR. LN-MTV value was not statistically significant in regression analysis (p = 0.456).
Conclusion: As a result of this retrospective study, it was observed that the group with high LN-TLG, one of the PET/CT parameters, had more pCR.
期刊介绍：
With the first issue in 2014, the journal ''Onkologie'' has changed its title to ''Oncology Research and Treatment''. By this change, publisher and editor set the scene for the further development of this interdisciplinary journal. The English title makes it clear that the articles are published in English – a logical step for the journal, which is listed in all relevant international databases. For excellent manuscripts, a ''Fast Track'' was introduced: The review is carried out within 2 weeks; after acceptance the papers are published online within 14 days and immediately released as ''Editor’s Choice'' to provide the authors with maximum visibility of their results. Interesting case reports are published in the section ''Novel Insights from Clinical Practice'' which clearly highlights the scientific advances which the report presents.
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