Prognostic Factors and Long-Term Survival in Kaposi's Sarcoma Patients: Results from a 28-Year Retrospective Cohort.

Background and Objectives: Kaposi's sarcoma (KS) is a rare malignancy with limited prospective data. The aim of this study was to evaluate the clinical features and prognostic factors of KS in a cohort of patients treated at a single center. Materials and Methods: Records of 83 patients with KS were retrospectively analyzed. Patient demographics, clinical features, and treatments were analyzed. Univariate and multivariate analyses were performed to evaluate factors affecting overall survival (OS). Results: The median age of the cohort was 65 years, and 22.9% were female. The classical type of KS was the most common (84.3%), with the most common site of localization being the feet (30.2%). The 5-year and 10-year OS rates were 82.7% and 70.8%, respectively. Univariate analysis identified age, performance score (ECOG PS), lymph node involvement, and disease stage as significant prognostic factors. However, in multivariate analysis, only the ECOG PS remained a significant predictor of OS. Conclusions: KS is a condition that requires long-term follow-up, and performance status is particularly critical for patient survival. In addition to our findings, comprehensive prospective studies are still needed to better understand the factors influencing patient survival in KS.