烟雾病患者联合血运重建术后网络中心性的改变：静息状态fMRI研究

IF 1.6 4区医学 Q4 NEUROSCIENCES

Neuroreport Pub Date : 2025-06-04 Epub Date: 2025-05-14 DOI:10.1097/WNR.0000000000002154

Yuanyuan Wang, Jian Li, Feng Lin, Junwei Gao, Zihe Xu, Jie Liu, Xianjun Zeng

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引用次数: 0

摘要

目的：本研究旨在探讨烟雾病（MMD）患者联合血运重建术（CRS）前后脑网络特征的变化。方法：本研究招募了20名烟雾病患者和20名年龄和性别匹配的健康对照（hc）。所有参与者都接受了核磁共振扫描。此外，烟雾病患者接受了全面的临床评估。利用度中心性（DC）分析评估整个脑网络的连通性特征。本研究还检测了烟雾病患者在crs前（pre-CRS）和crs后（post-CRS）的DC值与各种临床指标之间的相关性。结果：与hc相比，crs前MMD患者多脑区DC值异常，主要包括小脑、额叶、颞叶、扣带回。CRS治疗1年后，双侧小脑后叶DC值呈相反升高。此外，crs前MMD患者右小脑后叶DC值与蒙特利尔认知评估评分呈正相关。结论：CRS治疗可有效改善烟雾病所致双侧小脑后叶功能网络损伤，有望为评价CRS治疗疗效提供新的神经影像学指标。

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Network centrality alterations in patients with moyamoya disease after combined revascularization surgery: a resting-state fMRI study.

Objective: This study aimed to explore alterations in brain network characteristics among patients with moyamoya disease (MMD) before and after combined revascularization surgery (CRS).

Methods: This investigation enrolled 20 MMD patients alongside 20 age- and sex-matched healthy controls (HCs). All participants underwent MRI scans. Additionally, MMD patients were subjected to comprehensive clinical assessments. Degree centrality (DC) analysis was utilized to assess the connectivity features of the entire brain network. The study also examined correlations between DC values in MMD patients before- (pre-CRS) and after-CRS (post-CRS) and various clinical indicators.

Results: Compared with HCs, pre-CRS MMD patients showed abnormal DC values in multiple brain regions, mainly including the cerebellum, frontal lobe, temporal lobe, and cingulate gyrus. One year after CRS treatment, the DC values of the bilateral cerebellum posterior lobe showed a reverse increase. In addition, the DC value of the right cerebellum posterior lobe in pre-CRS MMD patients was positively correlated with the Montreal cognitive assessment scores.

Conclusions: CRS treatment can effectively improve the functional network damage of the bilateral cerebellum posterior lobes caused by MMD, and it is expected to provide a new neuroimaging marker for the evaluation of CRS treatment efficacy.

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来源期刊

Neuroreport 医学-神经科学

CiteScore

3.20

自引率

0.00%

发文量

150

审稿时长

1 months

期刊介绍： NeuroReport is a channel for rapid communication of new findings in neuroscience. It is a forum for the publication of short but complete reports of important studies that require very fast publication. Papers are accepted on the basis of the novelty of their finding, on their significance for neuroscience and on a clear need for rapid publication. Preliminary communications are not suitable for the Journal. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool. The core interest of the Journal is on studies that cast light on how the brain (and the whole of the nervous system) works. We aim to give authors a decision on their submission within 2-5 weeks, and all accepted articles appear in the next issue to press.