癌症幸存者暴露于烟草相关毒物和氧化应激的生物标志物。

IF 3 2区 医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Hongying Daisy Dai, Yi Hao, Mona Periera, Tzeyu Michaud
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引用次数: 0

摘要

导言:继续使用烟草制品的癌症幸存者可能对其长期健康结果产生负面影响。方法:数据来自烟草与健康人口评估研究第5期(n=6946)。采用加权线性回归对人口统计因素进行调整,比较了癌症幸存者和非癌症成年人的四类有害和潜在有害成分生物标志物的几何平均浓度,以及氧化应激生物标志物。在癌症幸存者中,还比较了目前吸烟和使用电子烟的状况。结果:与非癌症成人(n=6441)相比,癌症幸存者(n=505)表现出更高的4-(甲基亚硝基氨基)-1-(3-吡啶基)-1-丁醇(NNAL, 10.9 vs. 6.7 pg/mg肌酐)、镉(0.3 vs. 0.2 ng/mg肌酐)、铅(0.4 vs. 0.3 ng/mg肌酐)、n-乙酰基- s -(2-羧乙基)- l-半胱氨酸(CEMA), 156.6 vs. 128.3 ng/mg肌酐)和8-异前列腺素(521.6 vs. 441.5 pg/mg肌酐)的平均浓度。在癌症幸存者中,纯吸烟者和双吸烟者的尿液尼古丁代谢物(即尼古丁当量[TNE2]和可替宁)、NNAL、镉、挥发性有机化合物(VOCs)和8-异前列腺素的平均浓度都高于非吸烟者。纯电子烟使用者尼古丁代谢物的平均浓度也更高(TNE2, 4.1 vs. 0.01)。结论:纯电子烟和双重使用都会增加癌症幸存者接触烟草相关毒物的风险。只吸电子烟也会增加尼古丁成瘾和氧化应激的风险。癌症幸存者需要戒除所有烟草使用,以改善健康结果。启示:癌症幸存者是烟草使用的高危人群。这项研究为癌症幸存者和非癌症成年人之间烟草相关毒物暴露的生物标志物差异提供了重要见解,并为吸烟和使用电子烟对健康的影响提供了证据。研究结果强调需要进行临床监测和有针对性的公共卫生干预,以鼓励戒烟,包括解决卷烟和电子烟的双重使用问题,以提高癌症幸存者的长期健康结果和生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biomarkers of Exposure to Tobacco-Related Toxicants and Oxidative Stress among Cancer Survivors.

Introduction: Cancer survivors who continue to use tobacco products may have negative impacts on their long-term health outcomes.

Methods: Data were drawn from the Population Assessment of Tobacco and Health Study Wave 5 (n=6946). Geometric mean concentrations of biomarkers from four classes of harmful and potentially harmful constituents, along with a biomarker of oxidative stress, were compared between cancer survivors and non-cancer adults using weighted linear regressions adjusted for demographic factors. Among cancer survivors, comparisons were also made across current cigarette smoking and e-cigarette use statuses.

Results: Compared to non-cancer adults (n=6441), cancer survivors (n=505) exhibited higher mean concentrations of 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanol (NNAL, 10.9 vs. 6.7 pg/mg creatinine), cadmium (0.3 vs. 0.2 ng/mg creatinine), lead (0.4 vs. 0.3 ng/mg creatinine), N-Acetyl-S-(2-carboxyethyl)-L-cysteine (CEMA), 156.6 vs. 128.3 ng/mg creatinine), and 8-isoprostane (521.6 vs. 441.5 pg/mg creatinine) in the unadjusted analyses. Among cancer survivors, both exclusive cigarette smokers and dual users had higher mean concentrations of urine nicotine metabolites (i.e., nicotine equivalents [TNE2], and cotinine), NNAL, cadmium, volatile organic compounds (VOCs), and 8-isoprostane than non-tobacco users. Exclusive e-cigarette users also had higher mean concentrations of nicotine metabolites (TNE2, 4.1 vs. 0.01, p<.0001; cotinine, 288.1 vs. 0.4, p<.0001), NNAL (5.6 vs. 1.7, p=.03), cadmium (0.4 vs. 0.3, p=.01), and 8-isoprostane (594.2 vs. 482.5, p=.03) than non-tobacco users.

Conclusions: Both exclusive smoking and dual use pose elevated risks of exposure to tobacco-related toxicants to cancer survivors. Exclusive e-cigarette use also increases the risk of nicotine addiction and oxidative stress. Abstinence of all tobacco use among cancer survivors is needed to improve health outcomes.

Implications: Cancer survivors represent a high-risk group for tobacco use. This study offers important insights into differences in biomarkers of tobacco-related toxicant exposure between cancer survivors and non-cancer adults and provides evidence of the health impacts associated with cigarette smoking and e-cigarette use. The findings emphasize the need for clinical monitoring and targeted public health interventions to encourage tobacco cessation, including addressing dual use of cigarettes and e-cigarettes, in order to enhance long-term health outcomes and quality of life for cancer survivors.

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来源期刊
Nicotine & Tobacco Research
Nicotine & Tobacco Research 医学-公共卫生、环境卫生与职业卫生
CiteScore
8.10
自引率
10.60%
发文量
268
审稿时长
3-8 weeks
期刊介绍: Nicotine & Tobacco Research is one of the world''s few peer-reviewed journals devoted exclusively to the study of nicotine and tobacco. It aims to provide a forum for empirical findings, critical reviews, and conceptual papers on the many aspects of nicotine and tobacco, including research from the biobehavioral, neurobiological, molecular biologic, epidemiological, prevention, and treatment arenas. Along with manuscripts from each of the areas mentioned above, the editors encourage submissions that are integrative in nature and that cross traditional disciplinary boundaries. The journal is sponsored by the Society for Research on Nicotine and Tobacco (SRNT). It publishes twelve times a year.
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