网格蛋白是一种膜裂变蛋白吗？

IF 18.1 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2025-08-01 Epub Date: 2025-04-19 DOI:10.1016/j.tcb.2025.03.005

Ling-Gang Wu, Lisi Wei, Michael M Kozlov

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引用次数: 0

摘要

膜裂变被认为涉及螺旋形成的蛋白质收缩Ω-shaped轮廓的颈部。最近的研究表明，膜孔包覆蛋白，尤其是网格蛋白，也可能通过Ω-profile基部或头部的聚合介导裂变，从而产生颈部收缩，这是之前被认为与网格蛋白（Ω-profile头部）无关的各种内吞模式的基础。

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Is clathrin a membrane fission protein?

Membrane fission is thought to involve helix-forming proteins to constrict the Ω-shaped profile's neck. Recent studies suggest that membrane pit-coating proteins, especially clathrin, may also mediate fission via polymerization on the Ω-profile's base or head to generate neck constriction, which underlies various endocytic modes previously attributed as clathrin (Ω-profile head) independent.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.