17岁患者肌酸负荷后急性肾损伤伴铸型肾病。

IF 2.6 3区医学 Q1 PEDIATRICS

Pediatric Nephrology Pub Date : 2025-04-30 DOI:10.1007/s00467-025-06784-4

Guido Filler, Eugene Maung, Maria Esther Díaz González de Ferris, Nancy Gain Chan, Ajay Parkash Sharma

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引用次数: 0

摘要

该病例强调了一名17岁男性，在6天高剂量肌酸负荷治疗后发生急性肾损伤（AKI）并铸型肾病。患者表现为双侧侧腹疼痛，胱抑素C和肌酐平行升高，超声显示肾增大，尽管补水充足且无横纹肌溶解标志物。肾活检证实铸型肾病，无轻链病变。该病例强调了青少年使用大剂量肌酸的潜在风险，并强调了在使用运动补充剂的运动员中监测肾功能的重要性。

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Acute kidney injury with cast nephropathy following creatine loading in a 17-year-old.

This case highlights a 17-year-old male who developed acute kidney injury (AKI) with cast nephropathy following a 6-day high-dose creatine loading regimen. The patient presented with bilateral flank pain, a parallel rise in cystatin C and creatinine, and kidney enlargement on ultrasound despite adequate hydration and the absence of rhabdomyolysis markers. Renal biopsy confirmed cast nephropathy without evidence of light chain disease. This case underscores the potential risks of high-dose creatine use in adolescents and highlights the importance of kidney function monitoring in athletes using sports supplements.

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来源期刊

Pediatric Nephrology 医学-泌尿学与肾脏学

CiteScore

4.70

自引率

20.00%

发文量

465

审稿时长

1 months

期刊介绍： International Pediatric Nephrology Association Pediatric Nephrology publishes original clinical research related to acute and chronic diseases that affect renal function, blood pressure, and fluid and electrolyte disorders in children. Studies may involve medical, surgical, nutritional, physiologic, biochemical, genetic, pathologic or immunologic aspects of disease, imaging techniques or consequences of acute or chronic kidney disease. There are 12 issues per year that contain Editorial Commentaries, Reviews, Educational Reviews, Original Articles, Brief Reports, Rapid Communications, Clinical Quizzes, and Letters to the Editors.