Deepashri Agrawal, Palash Kumar Malo, Sadhana Singh, Thomas Gregor Issac
{"title":"印度人群听力损失及其与认知的关系：一项行为和神经影像学研究。","authors":"Deepashri Agrawal, Palash Kumar Malo, Sadhana Singh, Thomas Gregor Issac","doi":"10.1002/dad2.70106","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Hearing loss (HL) is an unexplored modifiable risk factor that impacts 41% of the Indian population. This study aimed to determine the prevalence of HL, investigate the association between HL and cognitive impairment in older adults, and assess neuronal structures involved in HL and cognitive impairment using behavioral and magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>This study assessed 589 individuals aged 45 and above using HearCheck handheld audiometry, cognitive testing, and MRI.</p><p><strong>Results: </strong>Participants with HL are 1.69 times more likely to experience cognitive impairment compared to those without HL. Neuroimaging revealed significantly less gray matter in various temporal and hippocampal regions in individuals with HL and cognitive impairment as compared with normal hearing and normal cognition.</p><p><strong>Discussion: </strong>These findings underscore the importance of exploring the link between sensory impairments, specifically HL, and cognitive impairment, emphasizing the need for preventive strategies in diverse populations.</p><p><strong>Highlights: </strong>A large urban cohort provides insights into hearing and cognitive function.Hearing loss (HL) is associated with a 69% higher likelihood of cognitive impairment.Magnetic resonance imaging (MRI) reveals reduced gray matter (GM) loss in individuals with HL.Comprehensive cognitive and hearing evaluations strengthen findings.Findings align with sensory deprivation and shared risk factor hypotheses.</p>","PeriodicalId":53226,"journal":{"name":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","volume":"17 2","pages":"e70106"},"PeriodicalIF":4.0000,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012993/pdf/","citationCount":"0","resultStr":"{\"title\":\"Hearing loss and its relation to cognition in Indian cohort: A behavioral and neuroimaging study.\",\"authors\":\"Deepashri Agrawal, Palash Kumar Malo, Sadhana Singh, Thomas Gregor Issac\",\"doi\":\"10.1002/dad2.70106\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Hearing loss (HL) is an unexplored modifiable risk factor that impacts 41% of the Indian population. This study aimed to determine the prevalence of HL, investigate the association between HL and cognitive impairment in older adults, and assess neuronal structures involved in HL and cognitive impairment using behavioral and magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>This study assessed 589 individuals aged 45 and above using HearCheck handheld audiometry, cognitive testing, and MRI.</p><p><strong>Results: </strong>Participants with HL are 1.69 times more likely to experience cognitive impairment compared to those without HL. Neuroimaging revealed significantly less gray matter in various temporal and hippocampal regions in individuals with HL and cognitive impairment as compared with normal hearing and normal cognition.</p><p><strong>Discussion: </strong>These findings underscore the importance of exploring the link between sensory impairments, specifically HL, and cognitive impairment, emphasizing the need for preventive strategies in diverse populations.</p><p><strong>Highlights: </strong>A large urban cohort provides insights into hearing and cognitive function.Hearing loss (HL) is associated with a 69% higher likelihood of cognitive impairment.Magnetic resonance imaging (MRI) reveals reduced gray matter (GM) loss in individuals with HL.Comprehensive cognitive and hearing evaluations strengthen findings.Findings align with sensory deprivation and shared risk factor hypotheses.</p>\",\"PeriodicalId\":53226,\"journal\":{\"name\":\"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring\",\"volume\":\"17 2\",\"pages\":\"e70106\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-04-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012993/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/dad2.70106\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer''s and Dementia: Diagnosis, Assessment and Disease Monitoring","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/dad2.70106","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Hearing loss and its relation to cognition in Indian cohort: A behavioral and neuroimaging study.
Introduction: Hearing loss (HL) is an unexplored modifiable risk factor that impacts 41% of the Indian population. This study aimed to determine the prevalence of HL, investigate the association between HL and cognitive impairment in older adults, and assess neuronal structures involved in HL and cognitive impairment using behavioral and magnetic resonance imaging (MRI).
Methods: This study assessed 589 individuals aged 45 and above using HearCheck handheld audiometry, cognitive testing, and MRI.
Results: Participants with HL are 1.69 times more likely to experience cognitive impairment compared to those without HL. Neuroimaging revealed significantly less gray matter in various temporal and hippocampal regions in individuals with HL and cognitive impairment as compared with normal hearing and normal cognition.
Discussion: These findings underscore the importance of exploring the link between sensory impairments, specifically HL, and cognitive impairment, emphasizing the need for preventive strategies in diverse populations.
Highlights: A large urban cohort provides insights into hearing and cognitive function.Hearing loss (HL) is associated with a 69% higher likelihood of cognitive impairment.Magnetic resonance imaging (MRI) reveals reduced gray matter (GM) loss in individuals with HL.Comprehensive cognitive and hearing evaluations strengthen findings.Findings align with sensory deprivation and shared risk factor hypotheses.
期刊介绍：
Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.
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