1例年轻艾滋病患者播散性组织浆菌病引起的噬血细胞性淋巴组织细胞增多症。

IF 1 Q4 INFECTIOUS DISEASES

Journal of Global Infectious Diseases Pub Date : 2025-02-24 eCollection Date: 2025-01-01 DOI:10.4103/jgid.jgid_150_24

Zachary Mostel, James Speed Rogers, Sushrita Neogi

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引用次数: 0

摘要

噬血细胞淋巴组织细胞增多症（HLH）是一种危及生命的免疫失调综合征，可导致多器官功能衰竭；HIV和组织胞浆菌病是已知的HLH诱因。一位年轻的艾滋病患者被发现患有播散性组织胞浆菌病，符合HLH的标准。尽管用两性霉素B脂质体治疗了10天，她还是出现了休克和急性呼吸窘迫综合征，最终死亡。少数报道的艾滋病组织胞浆菌病引起的HLH病例提供了多种治疗方法。两性霉素联合化疗治疗HLH已经取得了成功的结果。在同时存在播散性组织浆菌病和艾滋病毒/艾滋病的情况下，可以根据具体情况考虑针对HLH的靶向治疗。

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Hemophagocytic Lymphohistiocytosis Due to Disseminated Histoplasmosis in a Young Patient with AIDS.

Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening syndrome of immune dysregulation that results in multiorgan failure; HIV and histoplasmosis are known triggers of HLH. A young patient with AIDS was found to have disseminated histoplasmosis and met criteria for HLH. Despite 10 days of treatment with liposomal amphotericin B, she developed shock and acute respiratory distress syndrome and ultimately died. The few reported cases of HLH due to histoplasmosis in AIDS offer a variety of treatment approaches. There have been successful outcomes combining amphotericin with chemotherapies for HLH. Targeted therapies for HLH may be considered on a case-by-case basis in the setting of concurrent disseminated histoplasmosis and HIV/AIDS.

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来源期刊

Journal of Global Infectious Diseases INFECTIOUS DISEASES-

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

29 weeks

期刊介绍： JGID encourages research, education and dissemination of knowledge in the field of Infectious Diseases across the world thus promoting translational research by striking a synergy between basic science, clinical medicine and public health. The Journal intends to bring together scientists and academicians in Infectious Diseases to promote translational synergy between Laboratory Science, Clinical Medicine and Public Health. The Journal invites Original Articles, Clinical Investigations, Epidemiological Analysis, Data Protocols, Case Reports, Clinical Photographs, review articles and special commentaries. Students, Residents, Academicians, Public Health experts and scientists are all encouraged to be a part of this initiative by contributing, reviewing and promoting scientific works and science.