从菖蒲果实中提取三种新的高氧化类柠檬素。

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-04-11 DOI:10.1080/10286020.2025.2482075

Han-Sheng Lv, Hou-Li Jiang, Yu-Jin Sun, Ping Ying, Qiang Zheng, Ling-Yi Kong, Jun Luo

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引用次数: 0

摘要

Agledulines L-N（1 - 3）是三种先前报道的具有A/ d环-二羟基结构特征和高度氧化的柠檬素，与三种已报道的化合物（4 - 6）一起从Aglaia edulis果实中分离得到。通过NMR、hresms、ECD光谱和圆二色激子手性方法对1 - 3的结构进行了表征。1和2上的呋喃环被氧化为γ-羟基丁烯内酯片段，半缩醛C-21的互变异构导致片段上的核磁共振信号消失。生物学评价表明，1 - 3通过抑制lps激活的RAW264.7巨噬细胞no释放而无抗炎活性。

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Three new limonoids with high oxidation from the fruits of Aglaia edulis.

Agledulines L-N (1 - 3), three previously undescribed limonoids with the A/D-ring-seco structural characteristics and high degree oxidation, along with the three reported compounds (4 - 6), were isolated from the fruits of Aglaia edulis. The structures of 1 - 3 were elucidated by NMR data, HRESIMS, ECD spectra, and circular dichroism exciton chirality method. The furan rings in 1 and 2 were oxidized to γ-hydroxy-butene lactone moiety, and the tautomerism of hemiacetal C-21 contributed to the disappearance of NMR signals in the segments. The biological evaluation showed that 1 - 3 had no anti-inflammatory activity by inhibiting NO release in LPS-activated RAW264.7 macrophages.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.