Connor J Doherty, Benjamin P Thompson, Paige J Rynne, Jou-Chung Chang, Alexis E Pulford-Thorpe, Sarah A Angus, Eva C M Fleming, Sean L Gartner, Jason S Au, Glen E Foster, Paolo B Dominelli
{"title":"β-肾上腺素能受体在年轻男性和女性增加单腿膝关节伸展过程中介导运动充血的作用。","authors":"Connor J Doherty, Benjamin P Thompson, Paige J Rynne, Jou-Chung Chang, Alexis E Pulford-Thorpe, Sarah A Angus, Eva C M Fleming, Sean L Gartner, Jason S Au, Glen E Foster, Paolo B Dominelli","doi":"10.1152/japplphysiol.00896.2024","DOIUrl":null,"url":null,"abstract":"<p><p>Previous research has identified a role for β-adrenergic receptors in mediating sex differences in blood pressure regulation at rest. β-receptors are also involved in the exercise hyperemia response during low-intensity small muscle mass exercise in males. However, less is known about β-adrenergic receptors in mediating local exercise hyperemia response during graded large muscle mass exercise in young males and females. We compared steady-state cardiorespiratory responses, leg blood flow (Q̇<sub>LEG</sub>), and leg vascular conductance (LVC) in 16 participants (8 females) at rest and during incremental knee extension exercise with and without complete nonselective β-adrenergic blockade using propranolol. Propranolol reduced absolute heart rate (HR), Q̇<sub>LEG</sub>, and LVC responses during exercise. Females had greater absolute increases in HR and lower absolute Q̇<sub>LEG</sub> and LVC during exercise. However, Q̇<sub>LEG</sub> and LVC responses to incremental exercise were not different by sex or propranolol, even after normalizing for differences in estimated quadriceps muscle mass. Females were also found to have greater dilation of the femoral artery, which was blunted to a greater extent with propranolol compared with males at absolute exercise intensities. In conclusion, β-adrenergic receptors did not play an important role in mediating the overall exercise hyperemia response in males or females, as the cardiovascular system prioritizes the preservation of oxygen delivery to the exercising muscle. However, β<sub>2</sub>-adrenergic receptors appear to play a distinct role in mediating sex differences in changes to vascular tone during exercise.<b>NEW & NOTEWORTHY</b> We examined the role of beta-adrenergic receptors (β-ARs) in mediating exercise hyperemia in males and females. No sex differences in leg blood flow or leg vascular conductance, but females exhibited greater dilation of the femoral artery (FA), and β-AR blockade blunted FA dilation in females at absolute exercise intensities. Findings highlight that exercise hyperemia is not reliant on β-ARs and suggest females rely more on β-ARs in mediating vascular tone during exercise.</p>","PeriodicalId":15160,"journal":{"name":"Journal of applied physiology","volume":" ","pages":"1664-1679"},"PeriodicalIF":3.3000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The role of β-adrenergic receptors in mediating exercise hyperemia during incremental single-leg knee extension in young males and females.\",\"authors\":\"Connor J Doherty, Benjamin P Thompson, Paige J Rynne, Jou-Chung Chang, Alexis E Pulford-Thorpe, Sarah A Angus, Eva C M Fleming, Sean L Gartner, Jason S Au, Glen E Foster, Paolo B Dominelli\",\"doi\":\"10.1152/japplphysiol.00896.2024\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Previous research has identified a role for β-adrenergic receptors in mediating sex differences in blood pressure regulation at rest. β-receptors are also involved in the exercise hyperemia response during low-intensity small muscle mass exercise in males. However, less is known about β-adrenergic receptors in mediating local exercise hyperemia response during graded large muscle mass exercise in young males and females. We compared steady-state cardiorespiratory responses, leg blood flow (Q̇<sub>LEG</sub>), and leg vascular conductance (LVC) in 16 participants (8 females) at rest and during incremental knee extension exercise with and without complete nonselective β-adrenergic blockade using propranolol. Propranolol reduced absolute heart rate (HR), Q̇<sub>LEG</sub>, and LVC responses during exercise. Females had greater absolute increases in HR and lower absolute Q̇<sub>LEG</sub> and LVC during exercise. However, Q̇<sub>LEG</sub> and LVC responses to incremental exercise were not different by sex or propranolol, even after normalizing for differences in estimated quadriceps muscle mass. Females were also found to have greater dilation of the femoral artery, which was blunted to a greater extent with propranolol compared with males at absolute exercise intensities. In conclusion, β-adrenergic receptors did not play an important role in mediating the overall exercise hyperemia response in males or females, as the cardiovascular system prioritizes the preservation of oxygen delivery to the exercising muscle. However, β<sub>2</sub>-adrenergic receptors appear to play a distinct role in mediating sex differences in changes to vascular tone during exercise.<b>NEW & NOTEWORTHY</b> We examined the role of beta-adrenergic receptors (β-ARs) in mediating exercise hyperemia in males and females. No sex differences in leg blood flow or leg vascular conductance, but females exhibited greater dilation of the femoral artery (FA), and β-AR blockade blunted FA dilation in females at absolute exercise intensities. Findings highlight that exercise hyperemia is not reliant on β-ARs and suggest females rely more on β-ARs in mediating vascular tone during exercise.</p>\",\"PeriodicalId\":15160,\"journal\":{\"name\":\"Journal of applied physiology\",\"volume\":\" \",\"pages\":\"1664-1679\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of applied physiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1152/japplphysiol.00896.2024\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/5 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of applied physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1152/japplphysiol.00896.2024","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/5 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
The role of β-adrenergic receptors in mediating exercise hyperemia during incremental single-leg knee extension in young males and females.
Previous research has identified a role for β-adrenergic receptors in mediating sex differences in blood pressure regulation at rest. β-receptors are also involved in the exercise hyperemia response during low-intensity small muscle mass exercise in males. However, less is known about β-adrenergic receptors in mediating local exercise hyperemia response during graded large muscle mass exercise in young males and females. We compared steady-state cardiorespiratory responses, leg blood flow (Q̇LEG), and leg vascular conductance (LVC) in 16 participants (8 females) at rest and during incremental knee extension exercise with and without complete nonselective β-adrenergic blockade using propranolol. Propranolol reduced absolute heart rate (HR), Q̇LEG, and LVC responses during exercise. Females had greater absolute increases in HR and lower absolute Q̇LEG and LVC during exercise. However, Q̇LEG and LVC responses to incremental exercise were not different by sex or propranolol, even after normalizing for differences in estimated quadriceps muscle mass. Females were also found to have greater dilation of the femoral artery, which was blunted to a greater extent with propranolol compared with males at absolute exercise intensities. In conclusion, β-adrenergic receptors did not play an important role in mediating the overall exercise hyperemia response in males or females, as the cardiovascular system prioritizes the preservation of oxygen delivery to the exercising muscle. However, β2-adrenergic receptors appear to play a distinct role in mediating sex differences in changes to vascular tone during exercise.NEW & NOTEWORTHY We examined the role of beta-adrenergic receptors (β-ARs) in mediating exercise hyperemia in males and females. No sex differences in leg blood flow or leg vascular conductance, but females exhibited greater dilation of the femoral artery (FA), and β-AR blockade blunted FA dilation in females at absolute exercise intensities. Findings highlight that exercise hyperemia is not reliant on β-ARs and suggest females rely more on β-ARs in mediating vascular tone during exercise.
期刊介绍:
The Journal of Applied Physiology publishes the highest quality original research and reviews that examine novel adaptive and integrative physiological mechanisms in humans and animals that advance the field. The journal encourages the submission of manuscripts that examine the acute and adaptive responses of various organs, tissues, cells and/or molecular pathways to environmental, physiological and/or pathophysiological stressors. As an applied physiology journal, topics of interest are not limited to a particular organ system. The journal, therefore, considers a wide array of integrative and translational research topics examining the mechanisms involved in disease processes and mitigation strategies, as well as the promotion of health and well-being throughout the lifespan. Priority is given to manuscripts that provide mechanistic insight deemed to exert an impact on the field.