总肾体积作为实体瘤患者肾小球滤过率的预测指标:一项前瞻性横断面分析。

IF 2.7 4区 医学 Q2 UROLOGY & NEPHROLOGY
Regis Otaviano Franca Bezerra, Fernando Louzada Strufaldi, Patricia Perola Dantas, Filipe Andrade, Renato A Caires, Elerson Carlos Costalonga, George Barbério Coura Filho, Luiz A Gil, Marcelo Tatit Sapienza, Giovanni Guido Cerri, Emmanuel A Burdmann, Veronica Torres Costa E Silva
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引用次数: 0

摘要

背景:尽管先前的数据表明,总肾体积(TKV)与测量的肾小球滤过率(mGFR)相关,但在肿瘤学领域的证据却很少。本研究的目的是评估在慢性肾脏病流行病学合作(CKD-EPI)估算方程中加入TKV是否能改善癌症患者肾小球滤过率(mGFR)的预测。方法:我们通过血浆51Cr-EDTA清除率评估2015年4月至2017年9月期间接受对比计算机断层扫描和GFR测量的实体瘤患者。估计GFR (eGFR)通过基于血清肌酐(eGFRcr)并结合血清胱抑素C (eGFRcr-cys)的CKD-EPI方程确定。我们使用了2009年的eGFRcr和2012年的eGFRcr-cys方程以及无比赛的2021年eGFRcr和eGFRcr-cys。TKV采用半自动分割程序测量,不包括非功能性组织。建立线性回归模型,以TKV和eGFR方程为预测因子,mGFR为结果。结果:我们纳入189例患者(中位年龄58.0[48.0-65.0]岁,49.2%为男性)。中位mGFR和TKV分别为82.7 (66.3-94.5)mL/min和303.1 (257.7-351.8)cm3。加入TKV后,2009年eGFRcr和2012年eGFRcr-cys方程的决定系数R2分别由0.62提高到0.73和0.73提高到0.80。对于2021 eGFRcr和eGFRcr-cys方程,R2分别从0.65提高到0.75和0.75提高到0.82。结论:这些结果表明,TKV测量改善了实体肿瘤患者与CKD-EPI方程相关的mGFR预测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Total kidney volume as a predictor of measured glomerular filtration rate in patients with solid tumors: a prospective cross-sectional analysis.

Background: Although previous data demonstrate that total kidney volume (TKV) correlates with measured glomerular filtration rate (mGFR), evidence is however scarce in the oncology setting. The aim of this is study is to evaluate whether adding TKV to the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimating equations improves the prediction of measured glomerular filtration rate (mGFR) in patients with cancer.

Methods: We evaluated patients with solid tumors between April 2015 and September 2017 who had undergone contrast computed tomography and GFR measurement through the plasma clearance of 51Cr-EDTA. Estimated GFR (eGFR) was determined through CKD-EPI equations based on serum creatinine (eGFRcr) and combined with serum cystatin C (eGFRcr-cys). We used the 2009 eGFRcr and 2012 eGFRcr-cys equations and the race-free 2021 eGFRcr, and eGFRcr-cys. TKV was measured using a semi-automatic segmentation program, excluding non-functional tissues. Linear regression models were built, with TKV and eGFR equations as predictors and mGFR as the outcome.

Results: We included 189 patients (median age 58.0 [48.0-65.0] years, 49.2% male). Median mGFR and TKV were 82.7 (66.3-94.5) mL/min and 303.1 (257.7-351.8) cm3, respectively. TKV improved the coefficient of determination (R2) when added to 2009 eGFRcr and 2012 eGFRcr-cys equations from 0.62 to 0.73 and 0.73 to 0.80, respectively. For the 2021 eGFRcr and eGFRcr-cys equations, R2 improved from 0.65 to 0.75 and 0.75 to 0.82, respectively.

Conclusion: These results suggest that TKV measurement improves the prediction of mGFR in association with the CKD-EPI equations in patients with solid tumors.

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来源期刊
Journal of Nephrology
Journal of Nephrology 医学-泌尿学与肾脏学
CiteScore
5.60
自引率
5.90%
发文量
289
审稿时长
3-8 weeks
期刊介绍: Journal of Nephrology is a bimonthly journal that considers publication of peer reviewed original manuscripts dealing with both clinical and laboratory investigations of relevance to the broad fields of Nephrology, Dialysis and Transplantation. It is the Official Journal of the Italian Society of Nephrology (SIN).
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