超越终点：端粒重复序列RNA （TERRA）对中枢神经系统疾病的潜在影响。

IF 5.3 2区生物学 Q2 CELL BIOLOGY

Journal of Molecular Cell Biology Pub Date : 2025-04-16 DOI:10.1093/jmcb/mjaf013

Hadjer Namous, Raghu Vemuganti

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引用次数: 0

摘要

端粒重复序列RNA （TERRA）是一类源自端粒并控制端粒动力学的非编码RNA （ncRNAs）。近年来的研究表明，TERRAs影响染色质结构和基因表达。TERRAs还可以在控制炎症、氧化应激、DNA损伤和细胞衰老方面发挥关键作用。这篇综述文章讨论了TERRAs在调节这些过程中的意义，特别是在中枢神经系统中。虽然我们对TERRAs的理解主要源于癌症研究，但它们在这些生理和病理途径中的参与突出了它们作为中枢神经系统疾病治疗靶点的潜力。

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Beyond the ends: Potential implications of Telomeric Repeat-Containing RNA (TERRA) for CNS Diseases.

Telomeric Repeat-Containing RNA (TERRA) is a class of noncoding RNAs (ncRNAs) emanating from telomeres and control telomere dynamics. Recent studies showed that TERRAs influence chromatin structure and gene expression. TERRAs can also play a crucial role in controlling inflammation, oxidative stress, DNA damage, and cellular senescence. This review article discussed the significance of TERRAs in modulating these processes, particularly in CNS. While our understanding of TERRAs largely stems from cancer research, their involvement in these physiologic and pathologic pathways highlights their potential as therapeutic targets for CNS disorders as well.

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来源期刊

Journal of Molecular Cell Biology CELL BIOLOGY-

CiteScore

9.60

自引率

1.80%

发文量

1383

期刊介绍： The Journal of Molecular Cell Biology ( JMCB ) is a full open access, peer-reviewed online journal interested in inter-disciplinary studies at the cross-sections between molecular and cell biology as well as other disciplines of life sciences. The broad scope of JMCB reflects the merging of these life science disciplines such as stem cell research, signaling, genetics, epigenetics, genomics, development, immunology, cancer biology, molecular pathogenesis, neuroscience, and systems biology. The journal will publish primary research papers with findings of unusual significance and broad scientific interest. Review articles, letters and commentary on timely issues are also welcome. JMCB features an outstanding Editorial Board, which will serve as scientific advisors to the journal and provide strategic guidance for the development of the journal. By selecting only the best papers for publication, JMCB will provide a first rate publishing forum for scientists all over the world.