{"title":"经颈静脉肝内门体分流术治疗肝硬化食管静脉曲张出血的临床疗效。","authors":"Qun Zhao, Qiong Zi, Guoqiang Dong, Yong Lu, Yingzhan Zhang","doi":"10.12669/pjms.41.4.11695","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To explore the clinical efficacy of transjugular intrahepatic portal vein shunt (TIPS) in treating esophageal variceal bleeding (EVB) of liver cirrhosis patients.</p><p><strong>Methods: </strong>Clinical data of 60 patients with liver cirrhosis and EVB, admitted to The Second Affiliated Hospital of Bengbu Medical College between from November 2017 to April 2024, were retrospectively analyzed. Of them, 31 received TIPS treatment (TIPS group), and 29 received treatment with somatostatin (SST group). Blood transfusion volume, hemostasis time, and the length of hospital stay were compared between the two groups. Hemodynamic status, gastric motility indicators, vascular endothelial function indicators, levels of total bilirubin (TBIL), albumin (ALB), and international normalized ratio (INR) of both groups were compared before and after the treatment. The rebleeding and prognosis of patients were assessed after 6 months of follow-up.</p><p><strong>Results: </strong>The blood transfusion volume, hemostasis time, and length of hospital stay were significantly lower in the TIPS group than in the SST group (<i>P</i><0.05). After the treatment, the hemodynamic status, gastric motility indicators, and vascular endothelial function indicators, in both groups significantly improved compared to those before treatment and were considerably better in patients treated by TIPS group compared to the SST group (<i>P</i><0.05). There were no significant changes in the pretreatment and post-treatment levels of TBIL, ALB, and INR between the two groups (<i>P</i>>0.05). After six months of follow-up, the TIPS group showed significantly lower re-bleeding and mortality rates than the SST group (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Compared with conventional drug therapy, TIPS treatment can more effectively regulate hemodynamic status, improve gastric motility and vascular endothelial function, and reduce re-bleeding and mortality of patients with liver cirrhosis complicated by EVB.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 4","pages":"1138-1144"},"PeriodicalIF":1.2000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022585/pdf/","citationCount":"0","resultStr":"{\"title\":\"Clinical efficacy of transjugular intrahepatic portosystemic shunt in treating esophageal variceal bleeding in patients with liver cirrhosis.\",\"authors\":\"Qun Zhao, Qiong Zi, Guoqiang Dong, Yong Lu, Yingzhan Zhang\",\"doi\":\"10.12669/pjms.41.4.11695\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To explore the clinical efficacy of transjugular intrahepatic portal vein shunt (TIPS) in treating esophageal variceal bleeding (EVB) of liver cirrhosis patients.</p><p><strong>Methods: </strong>Clinical data of 60 patients with liver cirrhosis and EVB, admitted to The Second Affiliated Hospital of Bengbu Medical College between from November 2017 to April 2024, were retrospectively analyzed. Of them, 31 received TIPS treatment (TIPS group), and 29 received treatment with somatostatin (SST group). Blood transfusion volume, hemostasis time, and the length of hospital stay were compared between the two groups. Hemodynamic status, gastric motility indicators, vascular endothelial function indicators, levels of total bilirubin (TBIL), albumin (ALB), and international normalized ratio (INR) of both groups were compared before and after the treatment. The rebleeding and prognosis of patients were assessed after 6 months of follow-up.</p><p><strong>Results: </strong>The blood transfusion volume, hemostasis time, and length of hospital stay were significantly lower in the TIPS group than in the SST group (<i>P</i><0.05). After the treatment, the hemodynamic status, gastric motility indicators, and vascular endothelial function indicators, in both groups significantly improved compared to those before treatment and were considerably better in patients treated by TIPS group compared to the SST group (<i>P</i><0.05). There were no significant changes in the pretreatment and post-treatment levels of TBIL, ALB, and INR between the two groups (<i>P</i>>0.05). After six months of follow-up, the TIPS group showed significantly lower re-bleeding and mortality rates than the SST group (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>Compared with conventional drug therapy, TIPS treatment can more effectively regulate hemodynamic status, improve gastric motility and vascular endothelial function, and reduce re-bleeding and mortality of patients with liver cirrhosis complicated by EVB.</p>\",\"PeriodicalId\":19958,\"journal\":{\"name\":\"Pakistan Journal of Medical Sciences\",\"volume\":\"41 4\",\"pages\":\"1138-1144\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022585/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pakistan Journal of Medical Sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.12669/pjms.41.4.11695\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pakistan Journal of Medical Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12669/pjms.41.4.11695","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Clinical efficacy of transjugular intrahepatic portosystemic shunt in treating esophageal variceal bleeding in patients with liver cirrhosis.
Objective: To explore the clinical efficacy of transjugular intrahepatic portal vein shunt (TIPS) in treating esophageal variceal bleeding (EVB) of liver cirrhosis patients.
Methods: Clinical data of 60 patients with liver cirrhosis and EVB, admitted to The Second Affiliated Hospital of Bengbu Medical College between from November 2017 to April 2024, were retrospectively analyzed. Of them, 31 received TIPS treatment (TIPS group), and 29 received treatment with somatostatin (SST group). Blood transfusion volume, hemostasis time, and the length of hospital stay were compared between the two groups. Hemodynamic status, gastric motility indicators, vascular endothelial function indicators, levels of total bilirubin (TBIL), albumin (ALB), and international normalized ratio (INR) of both groups were compared before and after the treatment. The rebleeding and prognosis of patients were assessed after 6 months of follow-up.
Results: The blood transfusion volume, hemostasis time, and length of hospital stay were significantly lower in the TIPS group than in the SST group (P<0.05). After the treatment, the hemodynamic status, gastric motility indicators, and vascular endothelial function indicators, in both groups significantly improved compared to those before treatment and were considerably better in patients treated by TIPS group compared to the SST group (P<0.05). There were no significant changes in the pretreatment and post-treatment levels of TBIL, ALB, and INR between the two groups (P>0.05). After six months of follow-up, the TIPS group showed significantly lower re-bleeding and mortality rates than the SST group (P<0.05).
Conclusions: Compared with conventional drug therapy, TIPS treatment can more effectively regulate hemodynamic status, improve gastric motility and vascular endothelial function, and reduce re-bleeding and mortality of patients with liver cirrhosis complicated by EVB.
期刊介绍：
It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad.
Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.
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