卵巢间质细胞和神经嵴。

IF 3.4 3区生物学 Q3 CELL BIOLOGY

Human Cell Pub Date : 2025-04-12 DOI:10.1007/s13577-025-01210-1

José-Luis Carrasco-Juan, Olga Tapia, Miriam González-Gómez, Abian Vega-Falcón, Sonia García-Hernández, Alexis Rufino-Gómez, Rafael Méndez-Medina, Hugo Álvarez-Arguelles Cabrera

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引用次数: 0

摘要

在我们寻找标记物来识别和研究卵巢间质细胞的过程中，我们利用免疫组织化学技术，并使用常规和共聚焦显微镜将结果可视化。我们成功地使用甾体生成因子- 1 （SF1）、雄激素受体（AR）和III类β-微管蛋白作为标记。SF1和AR特别强调了间质细胞的神经内细胞前体，这是之前在一个已发表的卵巢成熟囊性畸胎瘤病例和成年卵巢间质细胞中发现的。此外，III类β-微管蛋白的短暂表达可能与这些前体的神经内移位有关，并协同它们迁移到成年女性的卵巢。

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Ovarian Leydig cells and neural crests.

In our search for markers to identify and study ovarian Leydig cells, we utilized immunohistochemical techniques and visualized the results using conventional and confocal microscopy. We successfully employed steroidogenic factor- 1 (SF1), androgen receptor (AR), and class III β-tubulin as markers. SF1 and AR specifically highlighted the intraneural cell precursors of Leydig cells, which were previously identified in a published case of mature cystic teratoma of the ovary, and the adult ovarian Leydig cells. Furthermore, the transient expression of class III β-tubulin could be associated with the intraneural displacement of these precursors, cooperating in their migration to colonize the ovaries of adult women.

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来源期刊

Human Cell CELL BIOLOGY-

CiteScore

5.90

自引率

2.30%

发文量

176

审稿时长

4.5 months

期刊介绍： Human Cell is the official English-language journal of the Japan Human Cell Society. The journal serves as a forum for international research on all aspects of the human cell, encompassing not only cell biology but also pathology, cytology, and oncology, including clinical oncology. Embryonic stem cells derived from animals, regenerative medicine using animal cells, and experimental animal models with implications for human diseases are covered as well. Submissions in any of the following categories will be considered: Research Articles, Cell Lines, Rapid Communications, Reviews, and Letters to the Editor. A brief clinical case report focusing on cellular responses to pathological insults in human studies may also be submitted as a Letter to the Editor in a concise and short format. Not only basic scientists but also gynecologists, oncologists, and other clinical scientists are welcome to submit work expressing new ideas or research using human cells.