Exploring the potential of nanoemulgels for dermatological disorders.

Background and purpose: Nanoemulgels are an advanced innovation in dermatological formulations designed to treat various skin diseases. By combining the advantages of hydrogels and nanoemulsions, these hybrid systems optimise drug delivery and improve therapeutic results. Because of their nanoscale droplets, nanoemulsions improve solubility by increasing surface area and stability and bioavailability of medications.

Methods and results: When embedded in a hydrogel matrix, their transformation into nanoemulgels, provide regulated and prolonged drug release, ensuring sustained therapeutic action. The ability of nanoemulgels to penetrate deeply into the layers of skin and get past obstacles like the stratum corneum to improve drug penetration and efficacy makes them highly effective in dermatology. Since the gel component helps to reduce the surface and interfacial tension and a rise in spreading coefficient along with the viscosity. The benefits of using NEGs for external use include their thixotropic, greaseless, readily dispersed properties, longer shelf life, emollient, effortlessly removed, non-staining clear, cosmetically attractive and environment friendly characteristics.

Conclusions: By providing an overview of research on nanoemulgels' permeability mechanisms, pharmacokinetics, uses, properties and the difficulties involved in topical drug delivery for skin disorders, this review emphasises the potential of these materials as topical drug delivery systems in dermatology.