Iana Mizumukai de Araújo, Maria Victoria Figueiredo Rebolho, Mayra Macena Gomes, Vivian Marques Suen, Francisco José Albuquerque de Paula
{"title":"神经性厌食症患者的骨评估及身体成分与骨量的关系","authors":"Iana Mizumukai de Araújo, Maria Victoria Figueiredo Rebolho, Mayra Macena Gomes, Vivian Marques Suen, Francisco José Albuquerque de Paula","doi":"10.1007/s12020-025-04231-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Anorexia nervosa is a psychiatric disorder characterized by self-imposed fasting and significant weight loss, leading to nutrient deficiencies that disrupt bone metabolism. This cross-sectional observational study aimed to characterize the bone health of women with anorexia nervosa using dual-energy X-ray absorptiometry (DXA), trabecular bone score (TBS), and 3D shaper analysis.</p><p><strong>Methods: </strong>The study involved 12 women diagnosed with anorexia nervosa monitored by a multidisciplinary team and 11 control subjects. Both groups underwent blood sampling and assessments with DXA, TBS, and 3D shaper analysis.</p><p><strong>Results: </strong>The results indicated that areal bone mineral density (aBMD) and Z-scores at the total hip and femoral neck were significantly lower in the anorexia group compared to controls (p < 0.05). Additionally, the fat mass index was reduced in women with anorexia (p < 0.05). Appendicular lean mass index (ALMI) was similar between the two groups. 3D shaper analysis revealed that surface BMD (sBMD), volumetric BMD (vBMD), integral vBMD, and trabecular vBMD were generally lower in the anorexia group. Associations were found between proximal femur 3D parameters and total hip and femoral neck aBMD. Moreover, significant correlations were observed between total cortical vBMD, total cortical sBMD, integral vBMD, and TBS. ALMI was associated with total cortical thickness and showed a trend toward association with femoral neck Z-score.</p><p><strong>Conclusion: </strong>In addition to previous studies indicating bone impairment in AN using DXA and TBS, the present study suggests that the 3D Shaper is also capable of detecting bone loss in this disorder. Therefore, the data encourage the further studies to assess the role of the 3D Shaper in prediction of fracture.</p>","PeriodicalId":49211,"journal":{"name":"Endocrine","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Bone evaluation and relationship between body composition and bone mass in anorexia nervosa followed up by a multidisciplinary team.\",\"authors\":\"Iana Mizumukai de Araújo, Maria Victoria Figueiredo Rebolho, Mayra Macena Gomes, Vivian Marques Suen, Francisco José Albuquerque de Paula\",\"doi\":\"10.1007/s12020-025-04231-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Anorexia nervosa is a psychiatric disorder characterized by self-imposed fasting and significant weight loss, leading to nutrient deficiencies that disrupt bone metabolism. This cross-sectional observational study aimed to characterize the bone health of women with anorexia nervosa using dual-energy X-ray absorptiometry (DXA), trabecular bone score (TBS), and 3D shaper analysis.</p><p><strong>Methods: </strong>The study involved 12 women diagnosed with anorexia nervosa monitored by a multidisciplinary team and 11 control subjects. Both groups underwent blood sampling and assessments with DXA, TBS, and 3D shaper analysis.</p><p><strong>Results: </strong>The results indicated that areal bone mineral density (aBMD) and Z-scores at the total hip and femoral neck were significantly lower in the anorexia group compared to controls (p < 0.05). Additionally, the fat mass index was reduced in women with anorexia (p < 0.05). Appendicular lean mass index (ALMI) was similar between the two groups. 3D shaper analysis revealed that surface BMD (sBMD), volumetric BMD (vBMD), integral vBMD, and trabecular vBMD were generally lower in the anorexia group. Associations were found between proximal femur 3D parameters and total hip and femoral neck aBMD. Moreover, significant correlations were observed between total cortical vBMD, total cortical sBMD, integral vBMD, and TBS. ALMI was associated with total cortical thickness and showed a trend toward association with femoral neck Z-score.</p><p><strong>Conclusion: </strong>In addition to previous studies indicating bone impairment in AN using DXA and TBS, the present study suggests that the 3D Shaper is also capable of detecting bone loss in this disorder. Therefore, the data encourage the further studies to assess the role of the 3D Shaper in prediction of fracture.</p>\",\"PeriodicalId\":49211,\"journal\":{\"name\":\"Endocrine\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2025-04-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s12020-025-04231-w\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s12020-025-04231-w","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Bone evaluation and relationship between body composition and bone mass in anorexia nervosa followed up by a multidisciplinary team.
Purpose: Anorexia nervosa is a psychiatric disorder characterized by self-imposed fasting and significant weight loss, leading to nutrient deficiencies that disrupt bone metabolism. This cross-sectional observational study aimed to characterize the bone health of women with anorexia nervosa using dual-energy X-ray absorptiometry (DXA), trabecular bone score (TBS), and 3D shaper analysis.
Methods: The study involved 12 women diagnosed with anorexia nervosa monitored by a multidisciplinary team and 11 control subjects. Both groups underwent blood sampling and assessments with DXA, TBS, and 3D shaper analysis.
Results: The results indicated that areal bone mineral density (aBMD) and Z-scores at the total hip and femoral neck were significantly lower in the anorexia group compared to controls (p < 0.05). Additionally, the fat mass index was reduced in women with anorexia (p < 0.05). Appendicular lean mass index (ALMI) was similar between the two groups. 3D shaper analysis revealed that surface BMD (sBMD), volumetric BMD (vBMD), integral vBMD, and trabecular vBMD were generally lower in the anorexia group. Associations were found between proximal femur 3D parameters and total hip and femoral neck aBMD. Moreover, significant correlations were observed between total cortical vBMD, total cortical sBMD, integral vBMD, and TBS. ALMI was associated with total cortical thickness and showed a trend toward association with femoral neck Z-score.
Conclusion: In addition to previous studies indicating bone impairment in AN using DXA and TBS, the present study suggests that the 3D Shaper is also capable of detecting bone loss in this disorder. Therefore, the data encourage the further studies to assess the role of the 3D Shaper in prediction of fracture.
期刊介绍：
Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology.
Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted.
Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.
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