加纳库马西地区宫颈癌组织病理学特征及RIPK1和NF- κB表达分析。

IF 0.7 4区 医学 Q3 MEDICINE, GENERAL & INTERNAL
Nigerian Journal of Clinical Practice Pub Date : 2025-04-01 Epub Date: 2025-04-26 DOI:10.4103/njcp.njcp_520_24
B M Duduyemi, E K Addae, K Bedu-Addo, E Atta Manu, F R Ngongou
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引用次数: 0

摘要

背景:宫颈癌是加纳库马西第二大常见癌症。尽管在临床管理方面取得了进展,但生存率很低,这一事实需要探索其他方法来提高生存率。目的:综述宫颈癌与受体相互作用蛋白激酶1 (Receptor Interacting Protein Kinase 1, RIPK1)和核因子κB (Nuclear Factor κB, NF-κB)相关的组织病理学和分子特征,这些分子参与了炎症、细胞死亡和细胞存活的调控。材料与方法:本研究回顾了2015年1月至2016年12月在我中心连续诊断的135例病例。提取临床人口统计学数据,选择合适的福尔马林固定石蜡包埋(FFPE)组织块进行组织芯片构建,随后进行RIPK1和NF-κB表达的免疫组化评估。使用SPSS 26对数据进行统计分析。结果:患者平均年龄58.93岁,标准差为17.88岁。组织学类型以鳞状细胞癌(SCC)居多(96.3%)。组织学3级占多数(49.63%),其次为2级(33.32%)和1级(17.04%)。RIPK1和NF-κB均高表达(分别为56.6%和69.3%)。RIPK1表达与NF-κB表达显著相关(P = 0.001)。结论:RIPK1和NF-κB在高级别癌组织中显著共表达,提示它们在抑制细胞凋亡、提高生存和/或增殖的信号通路中具有活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of the Histopathological Characteristics and Expression of RIPK1 and NF- κB in Cervical Cancer in Kumasi, Ghana.

Background: Cervical cancer is the second most common cancer in Kumasi, Ghana. The fact that survival rates are low, despite the advances made in clinical management necessitates exploration of alternatives to improve survival.

Aim: This study reviews the histopathological and molecular characteristics of cervical cancer in relation to Receptor Interacting Protein Kinase 1 (RIPK1) and Nuclear Factor kappa B (NF-κB), which are involved in the regulation of inflammation, cell death and cell survival.

Materials and methods: The study reviewed 135 consecutive cases diagnosed from January 2015 to December 2016 in our centre. Clinicodemographic data were abstracted and suitable formalin fixed paraffin embedded (FFPE) tissue blocks were selected for tissue microarray construction and subsequent immunohistochemical assessment of RIPK1 and NF-κB expression. A statistical analysis of the data was done using SPSS version 26.

Results: The mean age of the cases was 58.93 years with a standard deviation of 17.88. The histological type of most (96.3%) of the cases was the Squamous cell carcinoma (SCC). Majority (49.63%) of the cases were of histological grade 3, followed by grade 2 with 33.32% and grade 1 with 17.04% of cases. Both RIPK1 and NF-κB were highly expressed (56.6% and 69.3%, respectively) among the case. RIPK1 expression was significantly associated with NF-κB expression (P = 0.001).

Conclusion: The significant co-expression of RIPK1 and NF-κB in the high-grade carcinomas suggest they are active in signalling pathways that supress apoptosis and enhance survival and/or proliferation.

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来源期刊
Nigerian Journal of Clinical Practice
Nigerian Journal of Clinical Practice MEDICINE, GENERAL & INTERNAL-
CiteScore
1.40
自引率
0.00%
发文量
275
审稿时长
4-8 weeks
期刊介绍: The Nigerian Journal of Clinical Practice is a Monthly peer-reviewed international journal published by the Medical and Dental Consultants’ Association of Nigeria. The journal’s full text is available online at www.njcponline.com. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal makes a token charge for submission, processing and publication of manuscripts including color reproduction of photographs.
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