B M Duduyemi, E K Addae, K Bedu-Addo, E Atta Manu, F R Ngongou
{"title":"加纳库马西地区宫颈癌组织病理学特征及RIPK1和NF- κB表达分析。","authors":"B M Duduyemi, E K Addae, K Bedu-Addo, E Atta Manu, F R Ngongou","doi":"10.4103/njcp.njcp_520_24","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cervical cancer is the second most common cancer in Kumasi, Ghana. The fact that survival rates are low, despite the advances made in clinical management necessitates exploration of alternatives to improve survival.</p><p><strong>Aim: </strong>This study reviews the histopathological and molecular characteristics of cervical cancer in relation to Receptor Interacting Protein Kinase 1 (RIPK1) and Nuclear Factor kappa B (NF-κB), which are involved in the regulation of inflammation, cell death and cell survival.</p><p><strong>Materials and methods: </strong>The study reviewed 135 consecutive cases diagnosed from January 2015 to December 2016 in our centre. Clinicodemographic data were abstracted and suitable formalin fixed paraffin embedded (FFPE) tissue blocks were selected for tissue microarray construction and subsequent immunohistochemical assessment of RIPK1 and NF-κB expression. A statistical analysis of the data was done using SPSS version 26.</p><p><strong>Results: </strong>The mean age of the cases was 58.93 years with a standard deviation of 17.88. The histological type of most (96.3%) of the cases was the Squamous cell carcinoma (SCC). Majority (49.63%) of the cases were of histological grade 3, followed by grade 2 with 33.32% and grade 1 with 17.04% of cases. Both RIPK1 and NF-κB were highly expressed (56.6% and 69.3%, respectively) among the case. RIPK1 expression was significantly associated with NF-κB expression (P = 0.001).</p><p><strong>Conclusion: </strong>The significant co-expression of RIPK1 and NF-κB in the high-grade carcinomas suggest they are active in signalling pathways that supress apoptosis and enhance survival and/or proliferation.</p>","PeriodicalId":19431,"journal":{"name":"Nigerian Journal of Clinical Practice","volume":"28 4","pages":"496-501"},"PeriodicalIF":0.7000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Analysis of the Histopathological Characteristics and Expression of RIPK1 and NF- κB in Cervical Cancer in Kumasi, Ghana.\",\"authors\":\"B M Duduyemi, E K Addae, K Bedu-Addo, E Atta Manu, F R Ngongou\",\"doi\":\"10.4103/njcp.njcp_520_24\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cervical cancer is the second most common cancer in Kumasi, Ghana. The fact that survival rates are low, despite the advances made in clinical management necessitates exploration of alternatives to improve survival.</p><p><strong>Aim: </strong>This study reviews the histopathological and molecular characteristics of cervical cancer in relation to Receptor Interacting Protein Kinase 1 (RIPK1) and Nuclear Factor kappa B (NF-κB), which are involved in the regulation of inflammation, cell death and cell survival.</p><p><strong>Materials and methods: </strong>The study reviewed 135 consecutive cases diagnosed from January 2015 to December 2016 in our centre. Clinicodemographic data were abstracted and suitable formalin fixed paraffin embedded (FFPE) tissue blocks were selected for tissue microarray construction and subsequent immunohistochemical assessment of RIPK1 and NF-κB expression. A statistical analysis of the data was done using SPSS version 26.</p><p><strong>Results: </strong>The mean age of the cases was 58.93 years with a standard deviation of 17.88. The histological type of most (96.3%) of the cases was the Squamous cell carcinoma (SCC). Majority (49.63%) of the cases were of histological grade 3, followed by grade 2 with 33.32% and grade 1 with 17.04% of cases. Both RIPK1 and NF-κB were highly expressed (56.6% and 69.3%, respectively) among the case. RIPK1 expression was significantly associated with NF-κB expression (P = 0.001).</p><p><strong>Conclusion: </strong>The significant co-expression of RIPK1 and NF-κB in the high-grade carcinomas suggest they are active in signalling pathways that supress apoptosis and enhance survival and/or proliferation.</p>\",\"PeriodicalId\":19431,\"journal\":{\"name\":\"Nigerian Journal of Clinical Practice\",\"volume\":\"28 4\",\"pages\":\"496-501\"},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nigerian Journal of Clinical Practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4103/njcp.njcp_520_24\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/26 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nigerian Journal of Clinical Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/njcp.njcp_520_24","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/26 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Analysis of the Histopathological Characteristics and Expression of RIPK1 and NF- κB in Cervical Cancer in Kumasi, Ghana.
Background: Cervical cancer is the second most common cancer in Kumasi, Ghana. The fact that survival rates are low, despite the advances made in clinical management necessitates exploration of alternatives to improve survival.
Aim: This study reviews the histopathological and molecular characteristics of cervical cancer in relation to Receptor Interacting Protein Kinase 1 (RIPK1) and Nuclear Factor kappa B (NF-κB), which are involved in the regulation of inflammation, cell death and cell survival.
Materials and methods: The study reviewed 135 consecutive cases diagnosed from January 2015 to December 2016 in our centre. Clinicodemographic data were abstracted and suitable formalin fixed paraffin embedded (FFPE) tissue blocks were selected for tissue microarray construction and subsequent immunohistochemical assessment of RIPK1 and NF-κB expression. A statistical analysis of the data was done using SPSS version 26.
Results: The mean age of the cases was 58.93 years with a standard deviation of 17.88. The histological type of most (96.3%) of the cases was the Squamous cell carcinoma (SCC). Majority (49.63%) of the cases were of histological grade 3, followed by grade 2 with 33.32% and grade 1 with 17.04% of cases. Both RIPK1 and NF-κB were highly expressed (56.6% and 69.3%, respectively) among the case. RIPK1 expression was significantly associated with NF-κB expression (P = 0.001).
Conclusion: The significant co-expression of RIPK1 and NF-κB in the high-grade carcinomas suggest they are active in signalling pathways that supress apoptosis and enhance survival and/or proliferation.
期刊介绍:
The Nigerian Journal of Clinical Practice is a Monthly peer-reviewed international journal published by the Medical and Dental Consultants’ Association of Nigeria. The journal’s full text is available online at www.njcponline.com. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal makes a token charge for submission, processing and publication of manuscripts including color reproduction of photographs.