人类疼痛神经科学和下一代疼痛疗法。

IF 14.7 1区医学 Q1 NEUROSCIENCES

Neuron Pub Date : 2025-05-07 DOI:10.1016/j.neuron.2025.04.005

Bryan A Copits, Michele Curatolo, Patrick M Dougherty, Robert W Gereau, Wenqin Luo, Maryann Martone, Hakan Olausson, Theodore J Price, William Renthal, Clifford J Woolf, Guoyan Zhao

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引用次数: 0

摘要

最近，suzetriine被批准用于急性疼痛治疗，这既突出了靶向外周感觉神经元治疗疼痛的成功，也突出了主要在人体系统中开发新的疼痛治疗方法的潜力。为了实现这种转变的潜力，进一步研究人体系统的体感和疼痛神经免疫学是必不可少的。

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Human pain neuroscience and the next generation of pain therapeutics.

The recent approval of suzetrigine for acute pain treatment highlights both the success of targeting peripheral sensory neurons for pain management and the potential of developing new pain therapies primarily in human-based systems. To realize this transformative potential, further research into somatosensation and pain neuroimmunology in human systems is essential.

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来源期刊

Neuron 医学-神经科学

CiteScore

24.50

自引率

3.10%

发文量

382

审稿时长

1 months

期刊介绍： Established as a highly influential journal in neuroscience, Neuron is widely relied upon in the field. The editors adopt interdisciplinary strategies, integrating biophysical, cellular, developmental, and molecular approaches alongside a systems approach to sensory, motor, and higher-order cognitive functions. Serving as a premier intellectual forum, Neuron holds a prominent position in the entire neuroscience community.