腹腔镜确认的子宫内膜异位症和NAFLD事件的风险：一项前瞻性队列研究。

IF 4.2 2区医学 Q1 ENDOCRINOLOGY & METABOLISM

Reproductive Biology and Endocrinology Pub Date : 2025-04-09 DOI:10.1186/s12958-025-01391-2

Hangkai Huang, Zhening Liu, Jiaqi Ruan, Zejun Fang, Chengfu Xu

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引用次数: 0

摘要

背景：探讨子宫内膜异位症是否与非酒精性脂肪性肝病（NAFLD）发生的风险相关。方法：从护士健康研究II中检索数据，随访时间为1995 - 2017年。这项前瞻性队列研究共纳入61649名参与者。本研究的暴露是腹腔镜确认子宫内膜异位症。我们进行了Cox比例风险回归分析，以估计子宫内膜异位症与NAFLD之间关联的风险比（HR）和95%置信区间（95% CI）。结果：在1,313,067人年的随访期间，共记录了4,774例NAFLD事件。在多变量调整模型中，腹腔镜确认的子宫内膜异位症与NAFLD的风险呈正相关（HR: 1.17, 95% CI: 1.07 - 1.29）。中介分析的结果显示，这种关联部分可归因于子宫/卵巢切除术（31.6%介导，95% CI: 18.8-47.9%）、高胆固醇血症、高血压和不孕症。进一步分析发现，年龄对子宫内膜异位症与NAFLD的相关性有显著的交互作用（P = 0.01）。结论：腹腔镜确认的子宫内膜异位症与NAFLD发生的风险呈正相关。在子宫内膜异位症的定期随访中，临床医生和患者应提高对潜在NAFLD风险的认识。

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Laparoscopically confirmed endometriosis and the risk of incident NAFLD: a prospective cohort study.

Background: To investigate whether endometriosis is associated with the risk of incident nonalcoholic fatty liver disease (NAFLD).

Methods: Data were retrieved from Nurses' Health Study II with participants followed up from 1995 to 2017. A total of 61,649 participants were included in this prospective cohort study. The exposure of this study was laparoscopically confirmed endometriosis. We performed Cox proportional hazard regression analyses to estimate the hazard ratio (HR) and 95% confidence interval (95% CI) of the association between endometriosis and NAFLD.

Results: A total of 4,774 incident NAFLD cases were recorded during a 1,313,067 person-years of follow-up. In the multivariable adjusted model, laparoscopically confirmed endometriosis was positively associated with the risk of NAFLD (HR: 1.17, 95% CI: 1.07 - 1.29). The results of the mediation analyses revealed that the association was partly attributable to hysterectomy/oophorectomy (31.6% mediated, 95% CI: 18.8-47.9%), hypercholesterolemia, hypertension and infertility. Further analysis revealed that the interaction effect of age was significant for the association between endometriosis and NAFLD (P = 0.01).

Conclusions: Laparoscopically confirmed endometriosis was positively associated with the risk of incident NAFLD. Awareness of the potential NAFLD risk should be raised for clinicians and patients during the regular follow-up of endometriosis.

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来源期刊

Reproductive Biology and Endocrinology 医学-内分泌学与代谢

CiteScore

7.90

自引率

2.30%

发文量

161

审稿时长

4-8 weeks

期刊介绍： Reproductive Biology and Endocrinology publishes and disseminates high-quality results from excellent research in the reproductive sciences. The journal publishes on topics covering gametogenesis, fertilization, early embryonic development, embryo-uterus interaction, reproductive development, pregnancy, uterine biology, endocrinology of reproduction, control of reproduction, reproductive immunology, neuroendocrinology, and veterinary and human reproductive medicine, including all vertebrate species.