Association Between Neutrophil Percentage to Serum Albumin Ratio and in-Hospital Mortality of Patients with Chronic Obstructive Pulmonary Disease in Intensive Care Unit: A Retrospective Cohort Study.

Objective: This study aimed to investigate the potential correlation between the neutrophil percentage to serum albumin ratio(NPAR) and in-hospital mortality in critically ill patients with Chronic Obstructive Pulmonary Disease (COPD).

Patients and methods: This study employed a retrospective cohort design. A total of 599 COPD patients were included in this research. Clinical data from the MIMIC-IV (Medical Information Mart for Intensive Care IV) database were utilized. To determine whether a correlation exists between NPAR and in-hospital mortality, a multivariable logistic regression analysis was conducted. Subgroup analyses were performed, taking into account factors such as age, sex, diabetes, congestive heart failure, and ventilator use.

Results: Among the 599 patients studied, 114 (19.0%) experienced in-hospital mortality. In the multivariable logistic regression model, NPAR was positively correlated with in-hospital mortality; for each unit increase in NPAR, the in-hospital mortality rate increased by 5% (Odds Ratio [OR] = 1.05; 95% Confidence Interval [95% CI] = 1.02-1.09). Compared to the lowest NPAR group, the highest NPAR group had a significantly greater risk of in-hospital mortality (OR [95% CI] = 2.15 [1.11-4.17]). Furthermore, the results of the subgroup analyses were consistent across all groups.

Conclusion: Our study reveals a correlation between NPAR levels and mortality in COPD patients. Further research is warranted to validate these findings.