现实生活中噻托溴铵对肺活量测定和哮喘控制的疗效:来自1年临床随访的数据。

IF 1.3 4区 医学 Q3 ALLERGY
Journal of Asthma Pub Date : 2025-09-01 Epub Date: 2025-05-08 DOI:10.1080/02770903.2025.2499823
Fatma Dindar Çelik, Kurtuluş Aksu, Enes Çelik, Hatice Çelik Tuğlu, Melis Yağdıran, Özgür Akkale, Onur Telli, Gözde Köycü Buhari, Sakine Nazik Bahçecioğlu, Funda Aksu
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引用次数: 0

摘要

目的:需要现实生活的研究来评估附加硫托溴铵治疗哮喘患者的临床结果。应用真实数据研究在哮喘患者治疗中加入噻托溴铵对肺功能和哮喘控制的影响。方法:在一项回顾性研究中,比较吸入皮质类固醇和长效β2激动剂联合治疗不能充分控制疾病的哮喘成人在使用噻托溴铵治疗前和治疗后1年的肺活量测量和哮喘控制状态。结果:噻托溴铵治疗1年后,平均FEV1、FEV1%、FEV1/FVC比值较治疗前显著升高。在32例因症状性哮喘而加入噻托溴铵治疗的患者中,28例(87.5%)患者年终达到良好控制(ACT≥20),4例(12.5%)患者GINA治疗降压。9例患者(28.1%)开始单克隆抗体治疗(mepolizumab或omalizumab)。FEV1值和FEV1/FVC比值与开始使用噻托溴铵治疗前的基线测量相比有统计学意义上的显著改善,与单克隆抗体的使用无关(p)。结论:噻托溴铵与ICS加LABA联合治疗是一种有效可靠的对症哮喘的补充治疗,也能改善呼吸功能和哮喘控制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Efficacy of tiotropium bromide on spirometric measurements and control of asthma in real life: data from a 1-year clinical follow-up.

Objective: Real-life studies are needed to evaluate the clinical outcomes of add-on tiotropium therapy in patients with asthma. The effects of adding tiotropium bromide to the treatment of asthmatic patients on pulmonary functions and asthma control using real-life data.

Methods: In a retrospective study, spirometric measures and asthma control states were compared before and one year after of tiotropium treatment in asthmatic adults whose disease was not adequately controlled with a combination of inhaled corticosteroids and long-acting β2-agonists.

Results: One year after tiotropium treatment, mean FEV1, FEV1%, and FEV1/FVC ratio increased significantly compared to pretreatment values. Among 32 patients added tiotropium due to symptomatic asthma, 28 (87.5%) patients achieved well-controlled (ACT ≥ 20) end of the year and GINA treatment step-down in 4 (12.5%) patients. Monoclonal antibody therapies (mepolizumab or omalizumab) were initiated in 9 patients (28.1%). FEV1 values and FEV1/FVC ratios showed a statistically significant improvement from baseline measurements obtained prior to the initiation of tiotropium therapy, independent of monoclonal antibody use (p < .001 for each). The mean age of these patients was 48.78 ± 11.64 (range: 28-81) years, and 25 (78.1%) of them were female.

Conclusions: Tiotropium bromide is an effective and reliable add-on therapy for symptomatic asthma when combined with ICS plus LABA, also leads to improvements in respiratory function and asthma control.

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来源期刊
Journal of Asthma
Journal of Asthma 医学-过敏
CiteScore
4.00
自引率
5.30%
发文量
158
审稿时长
3-8 weeks
期刊介绍: Providing an authoritative open forum on asthma and related conditions, Journal of Asthma publishes clinical research around such topics as asthma management, critical and long-term care, preventative measures, environmental counselling, and patient education.
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