线粒体转移驱动肿瘤微环境免疫逃避。

IF 17.5 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI:10.1016/j.trecan.2025.04.002

Qiang Cai, Xiaojun Cai, Quazi T H Shubhra

引用次数: 0

摘要

肿瘤通过多种机制破坏T细胞代谢。Ikeda等人揭示了线粒体转移是一种肿瘤驱动的免疫逃避策略，其中癌细胞将功能失调的线粒体传递给T细胞，损害代谢并诱导衰竭。这些发现突出了线粒体动力学作为改善免疫治疗结果的有希望的治疗靶点。

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Mitochondrial transfer drives immune evasion in tumor microenvironment.

Tumors subvert T cell metabolism through diverse mechanisms. Ikeda et al. reveal mitochondrial transfer as a tumor-driven immune evasion strategy, where cancer cells deliver dysfunctional mitochondria to T cells, impairing metabolism and inducing exhaustion. These findings highlight mitochondrial dynamics as a promising therapeutic target to improve immunotherapy outcomes.

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.