Marzieh Minaei, Akram Eidi, Pejman Mortazavi, Ahmad Asghari
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Protective effect of nano magnesium oxide on renal ischemia/reperfusion injury in male Wistar rats.
Ischemia/reperfusion (I/R) injury is a main issue in renal transplantation, and antioxidants attenuate I/R injury in different tissues. We investigated the protective effects of nano magnesium oxide (nano-MgO) on renal I/R injury in rats. Induction of I/R injury was performed through clamping the left renal pedicle for 20 minutes. Animals were administrated with nano-MgO (1.25, 2.5 and 5 mg/kg) for 30 days by gavage, and were sacrificed for biochemical and histopathological studies. Our findings show that nano-MgO administration (2.5 and 5 mg/kg) in rats with renal I/R injury significantly attenuated serum creatinine and urea levels (p<0.001), decreased malondialdehyde (MDA) levels and elevated antioxidant enzyme activities in renal homogenates (p<0.001), as evidenced by histopathological assessment, and caused a significant reduction in EGF immunoreactivity and EGFR expression in renal tissues (p<0.001). In conclusion, nano-MgO administration preserves renal function and prevents tissue damage after I/R injury in rats.
期刊介绍：
Magnesium Research, the official journal of the international Society for the Development of Research on Magnesium (SDRM), has been the benchmark journal on the use of magnesium in biomedicine for more than 30 years.
This quarterly publication provides regular updates on multinational and multidisciplinary research into magnesium, bringing together original experimental and clinical articles, correspondence, Letters to the Editor, comments on latest news, general features, summaries of relevant articles from other journals, and reports and statements from national and international conferences and symposiums.
Indexed in the leading medical databases, Magnesium Research is an essential journal for specialists and general practitioners, for basic and clinical researchers, for practising doctors and academics.
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