每日补充柠檬马鞭草提取物可降低表现亚临床注意缺陷多动障碍型行为的儿童的主观能量和家长报告的多动:一项随机对照试验。

IF 4.5 3区 医学 Q1 CLINICAL NEUROLOGY
Philippa A Jackson, Ellen F Smith, Joanne Forster, Jessica Greener, Anna Small, David O Kennedy, Cynthia G Suarez, Andressa Blainski, Ivo Pischel
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引用次数: 0

摘要

背景:目前针对注意缺陷多动障碍(ADHD)的治疗方案受到依从性和费用等因素的限制,而对于亚临床或未确诊的ADHD没有治疗方案。因此,草药制剂可以提供另一种治疗症状的方法;柠檬马鞭草Paláu (Aloysia citriodora)是一种很有前途的候选植物。目的:评估56天补充柠檬马鞭草提取物(LVE)对亚临床水平有ADHD症状的儿童的行为、认知、心理和生理影响。方法:本探索性研究采用随机双盲平行组设计,其中120名8-17岁的健康参与者接受15 mg/kg bw/d LVE或匹配安慰剂治疗56天。行为、认知、情绪和生理测量于基线和给药后28和56天在实验室收集。在整个研究过程中,父母也对孩子的行为进行了评估。结果:与安慰剂相比,接受LVE的参与者报告了更大的主观疲劳,根据情绪状态量表定义为能量水平降低,在56天的干预中,认知表现没有受损,第56天的抑郁症状也更低。LVE对父母多动/冲动行为评分的影响也接近显著性,积极治疗后报告的担忧较少。探索性分析显示对认知和情绪有进一步的好处。结论:本研究揭示了LVE补充剂对表现出高频率ADHD行为特征的儿童的有益作用。总的来说,LVE是安全的,参与者的耐受性良好,没有意外的安全事件。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Daily supplementation with lemon verbena extract decreases subjective energy and parental reports of hyperactivity in children displaying sub-clinical attention deficit hyperactivity disorder-type behaviours: A randomised controlled trial.

Background: Current treatment options for attention deficit hyperactivity disorder (ADHD) are limited by factors such as adherence and cost, whilst no treatment options are available for sub-clinical or undiagnosed ADHD. Herbal preparations may therefore offer an alternative approach to the management of symptoms; Aloysia citriodora Paláu (lemon verbena) is a promising candidate.

Aim: To assess the behavioural, cognitive, psychological and physiological effects of 56 days of supplementation with lemon verbena extract (LVE) in children exhibiting symptoms of ADHD at the sub-clinical level.

Methods: This exploratory study followed a randomised, double-blind parallel groups design wherein 120 healthy participants aged 8-17 years received 15 mg/kg bw/d LVE or matched placebo for 56 days. Behavioural, cognitive, mood and physiological measures were collected in the lab at baseline and 28 and 56 days post-dose. Parents also evaluated the child's behaviour throughout the study.

Results: Participants who received LVE reported greater subjective fatigue, defined as reduced energy levels according to the Profile of Mood States subscale, without impairments in cognitive performance across the 56-day intervention and lower depression symptoms on day 56, compared to placebo. The effect of LVE on parent ratings of hyperactive/impulsive behaviour also approached significance with fewer concerns being reported following the active treatment. Exploratory analyses showed further benefits to cognition and mood.

Conclusions: This study revealed novel, beneficial effects of LVE supplementation in children exhibiting a high frequency of behaviours characteristic of ADHD. Overall, LVE was safe and well-tolerated by participants, with no unexpected safety events.

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来源期刊
Journal of Psychopharmacology
Journal of Psychopharmacology 医学-精神病学
CiteScore
8.60
自引率
4.90%
发文量
126
审稿时长
3-8 weeks
期刊介绍: The Journal of Psychopharmacology is a fully peer-reviewed, international journal that publishes original research and review articles on preclinical and clinical aspects of psychopharmacology. The journal provides an essential forum for researchers and practicing clinicians on the effects of drugs on animal and human behavior, and the mechanisms underlying these effects. The Journal of Psychopharmacology is truly international in scope and readership.
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