心脏缺氧的代谢适应和治疗:机制和临床意义/潜在策略。

IF 8.4 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Huili Li, Fei Xiao, Chenghui Zhou, Tao Zhu, Sheng Wang
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引用次数: 0

摘要

心源性缺氧触发心肌和非心肌细胞的级联反应和功能改变,深刻影响细胞代谢、氧感应机制和免疫反应。心肌细胞是心脏组织的主要细胞类型,在缺氧条件下,心肌细胞通过糖酵解、脂肪酸代谢、酮体利用、支链氨基酸代谢等能量代谢发生显著变化,维持心功能。非心肌细胞,如成纤维细胞、内皮细胞和免疫细胞,虽然数量较少,但在调节心脏稳态、维持结构完整性和对损伤的反应中起着至关重要的作用。本文讨论了免疫细胞,特别是巨噬细胞在缺血-再灌注损伤过程中的代谢重编程,并探讨了各种调节这些代谢途径的治疗策略,以保护缺氧时的心脏。了解这些相互作用为心脏病治疗提供了有价值的见解和潜在的治疗靶点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metabolic Adaptations and Therapies in Cardiac Hypoxia: Mechanisms and Clinical Implications/ Potential Strategies.

Cardiac hypoxia triggers a cascade of responses and functional changes in myocardial and non-myocardial cells, profoundly affecting cellular metabolism, oxygen-sensing mechanisms, and immune responses. Myocardial cells, being the primary cell type in cardiac tissue, undergo significant alterations in energy metabolism, including glycolysis, fatty acid metabolism, ketone body utilization, and branched-chain amino acid metabolism, to maintain cardiac function under hypoxic conditions. Non-myocardial cells, such as fibroblasts, endothelial cells, and immune cells, although fewer in number, play crucial roles in regulating cardiac homeostasis, maintaining structural integrity, and responding to injury. This review discusses the metabolic reprogramming of immune cells, particularly macrophages, during ischemia-reperfusion injury and explores various therapeutic strategies that modulate these metabolic pathways to protect the heart during hypoxia. Understanding these interactions provides valuable insights and potential therapeutic targets for heart disease treatment.

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来源期刊
JACC: Basic to Translational Science
JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
14.20
自引率
1.00%
发文量
161
审稿时长
16 weeks
期刊介绍: JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.
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