常见的怀疑：呼吸道合胞病毒和鼻病毒驱动哮喘的发展和恶化。

IF 4.7 2区医学 Q1 ALLERGY

Annals of Allergy Asthma & Immunology Pub Date : 2025-09-01 DOI:10.1016/j.anai.2025.04.013

Victoria T. Nguyen DO , Kristina Roth MD , Emily Engelhardt MD , Adam Pearlstein DO , Theresia R. Davita MD , Mitchell H. Grayson MD

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引用次数: 0

摘要

反复发作的喘息和哮喘是主要的健康问题，尤其是儿童。已知呼吸道病毒感染可引起反复喘息和哮喘。与大多数复发性喘息和哮喘发展相关的两种呼吸道病毒是呼吸道合胞病毒（RSV）和鼻病毒（RV）。这篇综述检查了这两种病毒在喘息和哮喘的发展中所起的作用。对于那些在出生后2-6个月有严重感染且没有预先存在特应性反应的婴儿，呼吸道合胞病毒往往会导致反复喘息。这与RV相反，RV倾向于在已有特应性体质的患者中引起喘息和哮喘。在回顾中，已提出的机制，推动哮喘和喘息的发展进行了探讨。最后，讨论了新的发展，如疫苗。特别是，RSV的疫苗和治疗有可能改变复发性喘息的发展，而RV的疫苗和治疗仍然难以捉摸。RSV和RV仍然是幼儿反复喘息的主要来源。

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The usual suspects

Recurrent wheeze and asthma are major health problems, especially in children. Respiratory viral infections are known to induce recurrent wheeze and asthma. Two respiratory viruses associated with most recurrent wheeze and asthma development are respiratory syncytial virus (RSV) and rhinovirus (RV). This review evaluates the roles these 2 viruses play in the development of wheeze and asthma. RSV tends to drive recurrent wheeze in those infants who have a severe infection in the first 2 to 6 months of life and do not have preexisting atopy. This is in contrast with RV, which tends to drive wheeze and asthma in those with preexisting atopy. In the review, the mechanisms that have been proposed to drive the development of asthma and wheeze are explored. Finally, newer developments, such as vaccines, are discussed. In particular, vaccines and treatment for RSV have the potential to alter the development of recurrent wheezing, although vaccines and treatment for RV remain elusive. Both RSV and RV remain a major source of recurrent wheezing in young children.

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来源期刊

Annals of Allergy Asthma & Immunology 医学-过敏

CiteScore

6.50

自引率

6.80%

发文量

437

审稿时长

33 days

期刊介绍： Annals of Allergy, Asthma & Immunology is a scholarly medical journal published monthly by the American College of Allergy, Asthma & Immunology. The purpose of Annals is to serve as an objective evidence-based forum for the allergy/immunology specialist to keep up to date on current clinical science (both research and practice-based) in the fields of allergy, asthma, and immunology. The emphasis of the journal will be to provide clinical and research information that is readily applicable to both the clinician and the researcher. Each issue of the Annals shall also provide opportunities to participate in accredited continuing medical education activities to enhance overall clinical proficiency.