{"title":"功能基因组学鉴定了FDX1在动脉粥样硬化中的保护作用。","authors":"Nicole Wayne, Marie A. Guerraty","doi":"10.1038/s44161-025-00636-y","DOIUrl":null,"url":null,"abstract":"A multi-omics study in the Health for Life in Singapore (HELIOS) study uncovered novel associations among rs10488763, FDX1, the reverse cholesterol-transport pathway, and atheroprotection. This elegant functional genomics study illustrates the potential of integrated ‘-omics’ to uncover novel pathways and potential therapeutic targets.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 5","pages":"503-504"},"PeriodicalIF":10.8000,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Functional genomics identifies a protective role for FDX1 in atherosclerosis\",\"authors\":\"Nicole Wayne, Marie A. Guerraty\",\"doi\":\"10.1038/s44161-025-00636-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A multi-omics study in the Health for Life in Singapore (HELIOS) study uncovered novel associations among rs10488763, FDX1, the reverse cholesterol-transport pathway, and atheroprotection. This elegant functional genomics study illustrates the potential of integrated ‘-omics’ to uncover novel pathways and potential therapeutic targets.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"4 5\",\"pages\":\"503-504\"},\"PeriodicalIF\":10.8000,\"publicationDate\":\"2025-05-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-025-00636-y\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-025-00636-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Functional genomics identifies a protective role for FDX1 in atherosclerosis
A multi-omics study in the Health for Life in Singapore (HELIOS) study uncovered novel associations among rs10488763, FDX1, the reverse cholesterol-transport pathway, and atheroprotection. This elegant functional genomics study illustrates the potential of integrated ‘-omics’ to uncover novel pathways and potential therapeutic targets.
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