Rong Fu, Jia-Xiang Yin, Ping He, Yan Chen, Yi Luo, Ping-Guo Liu, Shuang-Ling Guo
{"title":"云南省哩市和两河县小兽脾肾巴尔通体感染的比较研究。","authors":"Rong Fu, Jia-Xiang Yin, Ping He, Yan Chen, Yi Luo, Ping-Guo Liu, Shuang-Ling Guo","doi":"10.3389/fvets.2025.1554633","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Bartonellosis is a zoonotic infectious disease caused by <i>Bartonella</i> spp. Small mammals are the most important hosts of <i>Bartonella</i> and play an important role in its long-term maintenance and spread. The multi-organ studies help understand the <i>Bartonella</i> prevalence of hosts more systematically and comprehensively. This study aimed to investigate the prevalence of <i>Bartonella</i> in small mammals and explore the genetic diversity of the infected strains and the influencing factors from Mile City and Lianghe County, Yunnan Province.</p><p><strong>Methods: </strong>Small mammals were captured in Mile City and Lianghe County of Yunnan Province from July to August 2019. Spleen and kidney tissues were collected and the <i>gltA</i> gene was amplified to detect and analyze the prevalence of <i>Bartonella</i> in two regions and two organs.</p><p><strong>Results: </strong>The prevalence of <i>Bartonella</i> in small mammals was 14.29% (43/301). Lianghe County's risk of infection was 3.79-fold (95%<i>CI</i>: 1.39-13.35) compared to that of Mile City. The risk of infection in <i>Rattus tanezumi</i> was increased by 90% compared to <i>Suncus murinus</i> (95%<i>CI</i>: 0.01-0.63). The small mammals with tail lengths > 132 mm infected by <i>Bartonella</i> were 6.34 folds than that with tail lengths ≤ 132 mm (95%<i>CI</i>: 1.87-23.39). The spleen had a higher infection rate of 12.11% (35/289) than the kidney at 7.33% (22/300) (<i>χ</i> <sup>2</sup> = 4.966, <i>p</i> = 0.026). There were no statistically significant differences in the prevalence of <i>Bartonella</i> among small mammals with different habitats, sex, age, flea infestation status, body weight, body length, hindfoot length, and ear height. Five <i>Bartonella</i> species were isolated in seven species of small mammals<i>. Bartonella tribocorum</i> is the dominant species in both regions, and it has a genetic relationship with the zoonotic pathogen <i>Bartonella elizabethae</i>.</p><p><strong>Conclusion: </strong>This study showed the prevalence of <i>Bartonella</i> in small mammals from Mile City and Lianghe County of Yunnan Province was high, and there were more types of <i>Bartonella</i> infection species. The spleen was more conducive to the growth and reproduction of <i>Bartonella</i>. The results of the study will help to prevent and control <i>Bartonella</i> infection and transmission to humans from small mammals in the two regions and provide a reference basis for further research on <i>Bartonella</i> infection in Yunnan or other similar regions.</p>","PeriodicalId":12772,"journal":{"name":"Frontiers in Veterinary Science","volume":"12 ","pages":"1554633"},"PeriodicalIF":2.6000,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041079/pdf/","citationCount":"0","resultStr":"{\"title\":\"Comparative study on <i>Bartonella</i> infection in spleen and kidney of small mammals from Mile City and Lianghe County, Yunnan Province.\",\"authors\":\"Rong Fu, Jia-Xiang Yin, Ping He, Yan Chen, Yi Luo, Ping-Guo Liu, Shuang-Ling Guo\",\"doi\":\"10.3389/fvets.2025.1554633\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Bartonellosis is a zoonotic infectious disease caused by <i>Bartonella</i> spp. Small mammals are the most important hosts of <i>Bartonella</i> and play an important role in its long-term maintenance and spread. The multi-organ studies help understand the <i>Bartonella</i> prevalence of hosts more systematically and comprehensively. This study aimed to investigate the prevalence of <i>Bartonella</i> in small mammals and explore the genetic diversity of the infected strains and the influencing factors from Mile City and Lianghe County, Yunnan Province.</p><p><strong>Methods: </strong>Small mammals were captured in Mile City and Lianghe County of Yunnan Province from July to August 2019. Spleen and kidney tissues were collected and the <i>gltA</i> gene was amplified to detect and analyze the prevalence of <i>Bartonella</i> in two regions and two organs.</p><p><strong>Results: </strong>The prevalence of <i>Bartonella</i> in small mammals was 14.29% (43/301). Lianghe County's risk of infection was 3.79-fold (95%<i>CI</i>: 1.39-13.35) compared to that of Mile City. The risk of infection in <i>Rattus tanezumi</i> was increased by 90% compared to <i>Suncus murinus</i> (95%<i>CI</i>: 0.01-0.63). The small mammals with tail lengths > 132 mm infected by <i>Bartonella</i> were 6.34 folds than that with tail lengths ≤ 132 mm (95%<i>CI</i>: 1.87-23.39). The spleen had a higher infection rate of 12.11% (35/289) than the kidney at 7.33% (22/300) (<i>χ</i> <sup>2</sup> = 4.966, <i>p</i> = 0.026). There were no statistically significant differences in the prevalence of <i>Bartonella</i> among small mammals with different habitats, sex, age, flea infestation status, body weight, body length, hindfoot length, and ear height. Five <i>Bartonella</i> species were isolated in seven species of small mammals<i>. Bartonella tribocorum</i> is the dominant species in both regions, and it has a genetic relationship with the zoonotic pathogen <i>Bartonella elizabethae</i>.</p><p><strong>Conclusion: </strong>This study showed the prevalence of <i>Bartonella</i> in small mammals from Mile City and Lianghe County of Yunnan Province was high, and there were more types of <i>Bartonella</i> infection species. The spleen was more conducive to the growth and reproduction of <i>Bartonella</i>. The results of the study will help to prevent and control <i>Bartonella</i> infection and transmission to humans from small mammals in the two regions and provide a reference basis for further research on <i>Bartonella</i> infection in Yunnan or other similar regions.</p>\",\"PeriodicalId\":12772,\"journal\":{\"name\":\"Frontiers in Veterinary Science\",\"volume\":\"12 \",\"pages\":\"1554633\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2025-04-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041079/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Veterinary Science\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.3389/fvets.2025.1554633\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Veterinary Science","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3389/fvets.2025.1554633","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Comparative study on Bartonella infection in spleen and kidney of small mammals from Mile City and Lianghe County, Yunnan Province.
Background: Bartonellosis is a zoonotic infectious disease caused by Bartonella spp. Small mammals are the most important hosts of Bartonella and play an important role in its long-term maintenance and spread. The multi-organ studies help understand the Bartonella prevalence of hosts more systematically and comprehensively. This study aimed to investigate the prevalence of Bartonella in small mammals and explore the genetic diversity of the infected strains and the influencing factors from Mile City and Lianghe County, Yunnan Province.
Methods: Small mammals were captured in Mile City and Lianghe County of Yunnan Province from July to August 2019. Spleen and kidney tissues were collected and the gltA gene was amplified to detect and analyze the prevalence of Bartonella in two regions and two organs.
Results: The prevalence of Bartonella in small mammals was 14.29% (43/301). Lianghe County's risk of infection was 3.79-fold (95%CI: 1.39-13.35) compared to that of Mile City. The risk of infection in Rattus tanezumi was increased by 90% compared to Suncus murinus (95%CI: 0.01-0.63). The small mammals with tail lengths > 132 mm infected by Bartonella were 6.34 folds than that with tail lengths ≤ 132 mm (95%CI: 1.87-23.39). The spleen had a higher infection rate of 12.11% (35/289) than the kidney at 7.33% (22/300) (χ2 = 4.966, p = 0.026). There were no statistically significant differences in the prevalence of Bartonella among small mammals with different habitats, sex, age, flea infestation status, body weight, body length, hindfoot length, and ear height. Five Bartonella species were isolated in seven species of small mammals. Bartonella tribocorum is the dominant species in both regions, and it has a genetic relationship with the zoonotic pathogen Bartonella elizabethae.
Conclusion: This study showed the prevalence of Bartonella in small mammals from Mile City and Lianghe County of Yunnan Province was high, and there were more types of Bartonella infection species. The spleen was more conducive to the growth and reproduction of Bartonella. The results of the study will help to prevent and control Bartonella infection and transmission to humans from small mammals in the two regions and provide a reference basis for further research on Bartonella infection in Yunnan or other similar regions.
期刊介绍：
Frontiers in Veterinary Science is a global, peer-reviewed, Open Access journal that bridges animal and human health, brings a comparative approach to medical and surgical challenges, and advances innovative biotechnology and therapy.
Veterinary research today is interdisciplinary, collaborative, and socially relevant, transforming how we understand and investigate animal health and disease. Fundamental research in emerging infectious diseases, predictive genomics, stem cell therapy, and translational modelling is grounded within the integrative social context of public and environmental health, wildlife conservation, novel biomarkers, societal well-being, and cutting-edge clinical practice and specialization. Frontiers in Veterinary Science brings a 21st-century approach—networked, collaborative, and Open Access—to communicate this progress and innovation to both the specialist and to the wider audience of readers in the field.
Frontiers in Veterinary Science publishes articles on outstanding discoveries across a wide spectrum of translational, foundational, and clinical research. The journal''s mission is to bring all relevant veterinary sciences together on a single platform with the goal of improving animal and human health.
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