阴道镜检查的改变在吸烟者中更常见，并且出现在更年轻的年龄。

IF 1.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

In vivo Pub Date : 2025-05-01 DOI:10.21873/invivo.13946

Diego Erasun Mora, Ana Vázquez Del Campo, Alazne DE Castro Momioto, Alberto Muñoz Solano, Jose Schneider

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引用次数: 0

摘要

背景/目的：吸烟是公认的高危人乳头瘤病毒（HR-HPV）诱发宫颈癌的辅助危险因素。本研究旨在评估吸烟对HR-HPV感染妇女阴道镜检查结果的具体影响。患者和方法：本研究考虑了在阴道镜检查后接受环电切手术（LLETZ）的hr - hpv阳性妇女。来自区域筛查项目的819例患者被纳入研究，其中320例为吸烟者，499例为非吸烟者。结果：吸烟者明显年轻化（41.1 vs 43.8）。53.3%, pv。67.9%, pv。44.0%, pv。17.8%, p = 0.055)。虽然在六个月时观察到的病毒清除率没有显着差异，但吸烟者在两年后的结果有恶化的趋势（p=0.07）。结论：任何数量的吸烟都与更差的阴道镜检查和组织病理学结果相关，而且这种情况发生在更年轻的年龄。

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Colposcopic Alterations Are More Frequent in Smokers and Appear at a Younger Age.

Background/aim: Tobacco use is a recognized cofactor risk for cervical cancer induced by high-risk Human Papilloma Virus (HR-HPV). This study aimed to evaluate the specific influence of tobacco use on colposcopic examination results in women infected by HR-HPV.

Patients and methods: HR-HPV-positive women undergoing a loop electrosurgical excision procedure (LLETZ) after colposcopic examination were considered for this study. A total of 819 patients from a regional screening program were included, of whom 320 were smokers and 499 non-smokers.

Results: Smokers were significantly younger (41.1 vs. 43.8, p<0.01), more frequently exhibited grade II colposcopic changes (63.9% vs. 53.3%, p<0.05), had worse histopathological outcomes (CIN2+: 75.7% vs. 67.9%, p<0.05; CIN3+: 51.4% vs. 44.0%, p<0.05), and higher rates of affected surgical margins, with borderline significance (22.6% vs. 17.8%, p=0.055). While no significant differences in viral clearance were observed at six months, smokers showed a trend toward worse outcomes at two years (p=0.07).

Conclusion: Smoking in any amount is associated with worse colposcopic and histopathological findings, and this occurs at younger ages.

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来源期刊

In vivo 医学-医学：研究与实验

CiteScore

4.20

自引率

4.30%

发文量

330

审稿时长

3-8 weeks

期刊介绍： IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.