泰国妇科癌症协会研究组的一项多中心回顾性队列研究显示,年龄在50 ~ 60岁之间宫颈癌筛查异常的妇女CIN2+的风险

IF 3.7 2区 医学 Q1 OBSTETRICS & GYNECOLOGY
Journal of Gynecologic Oncology Pub Date : 2025-09-01 Epub Date: 2025-04-07 DOI:10.3802/jgo.2025.36.e83
Nida Jareemit, Warangkana Kolaka, Jitima Tiyayon, Siriwan Tangjitgamol, Perapong Inthasorn, Ruai Kittikhun, Nuttavut Kantathavorn
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引用次数: 0

摘要

目的:研究bb0 ~ 60岁女性宫颈癌异常筛查模式,探讨宫颈上皮内瘤变2级及以上(CIN2+)的风险及预测因素。方法:这项回顾性队列研究调查了来自泰国8个癌症中心的1596名年龄在bb0 - 60岁之间宫颈癌筛查结果异常的妇女。接受子宫切除术的患者被排除在外。收集和分析患者特征、既往和当前宫颈癌筛查结果以及组织病理学资料。结果:平均年龄68.2±7.2岁。异常筛查结果为细胞学正常伴高危人乳头瘤病毒阳性(0.9%)、意义不明的非典型鳞状细胞(37.7%)、低级别鳞状上皮内病变(12%)、不典型鳞状细胞不能排除高级别病变(11.7%)、高级别鳞状上皮内病变(12.7%)、非典型腺细胞(20.1%)、鳞状细胞癌(4.3%)、腺癌(0.7%)。筛查异常妇女CIN2+的风险为17.9%(95%可信区间[CI]=16.1-19.8);在有组织病理学检查的患者中,风险为28.8% (95% CI=26.1-31.7)。单变量logistic回归分析显示,年龄在60 ~ 70岁之间、1年内的性行为、既往异常/未筛查、既往CIN2+病理、症状的存在和细胞学分级是CIN2+的显著预测因素。在多变量分析中,缺乏既往筛查(校正优势比4.05;95%可信区间= 1.91 - -8.60;结论:对于年龄在50 ~ 60岁之间的妇女,应根据其危险因素进行个体化的宫颈癌筛查,特别是那些从未接受过筛查的妇女。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Risk of CIN2+ in women aged >60 years with abnormal cervical cancer screening: a multicenter retrospective cohort study from the Thai Gynecologic Cancer Society research group.

Risk of CIN2+ in women aged >60 years with abnormal cervical cancer screening: a multicenter retrospective cohort study from the Thai Gynecologic Cancer Society research group.

Risk of CIN2+ in women aged >60 years with abnormal cervical cancer screening: a multicenter retrospective cohort study from the Thai Gynecologic Cancer Society research group.

Risk of CIN2+ in women aged >60 years with abnormal cervical cancer screening: a multicenter retrospective cohort study from the Thai Gynecologic Cancer Society research group.

Objective: To study patterns of abnormal cervical cancer screening in women aged >60 years and explore the risk and predictors of cervical intraepithelial neoplasia grade 2 or worse (CIN2+).

Methods: This retrospective cohort study examined 1,596 women aged >60 years with abnormal cervical cancer screening results from eight Thai cancer centers. Those who underwent hysterectomy were excluded. Patient characteristics, previous and current cervical cancer screening results, and histopathology data were collected and analyzed.

Results: Mean age was 68.2±7.2 years. The abnormal screening results were normal cytology with positive high-risk human papillomavirus (0.9%), atypical squamous cells of undetermined significance (37.7%), low-grade squamous intraepithelial lesion (12%), atypical squamous cell cannot exclude high-grade lesion (11.7%), high-grade squamous intraepithelial lesion (12.7%), atypical glandular cell (20.1%), squamous cell carcinoma (4.3%), and adenocarcinoma (0.7%). Risk of CIN2+ in women with abnormal screening was 17.9% (95% confidence interval [CI]=16.1-19.8); among those with available histopathology, the risk was 28.8% (95% CI=26.1-31.7). Univariable logistic regression showed that age >70 years, sexual activity within 1 year, previous abnormal/no screening, previous CIN2+ pathology, presence of symptoms, and high-grade cytology were significant predictors of CIN2+. In the multivariable analysis, lack of previous screening (adjusted odds ratio=4.05; 95% CI=1.91-8.60; p<0.001) and high-grade cytology (adjusted odds ratio=7.00; 95% CI=3.34-14.67; p<0.001) were independent predictors of CIN2+.

Conclusion: Continuing cervical cancer screening in women aged >60 years should be individualized based on their risk factors, particularly for those who have never been screened.

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来源期刊
Journal of Gynecologic Oncology
Journal of Gynecologic Oncology ONCOLOGY-OBSTETRICS & GYNECOLOGY
CiteScore
6.00
自引率
2.60%
发文量
84
审稿时长
>12 weeks
期刊介绍: The Journal of Gynecologic Oncology (JGO) is an official publication of the Asian Society of Gynecologic Oncology. Abbreviated title is ''J Gynecol Oncol''. It was launched in 1990. The JGO''s aim is to publish the highest quality manuscripts dedicated to the advancement of care of the patients with gynecologic cancer. It is an international peer-reviewed periodical journal that is published bimonthly (January, March, May, July, September, and November). Supplement numbers are at times published. The journal publishes editorials, original and review articles, correspondence, book review, etc.
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