浅针治疗慢性颈部疼痛:一项多中心随机对照试验方案与功能磁共振成像和DTI。

IF 2.5 3区 医学 Q2 CLINICAL NEUROLOGY
Journal of Pain Research Pub Date : 2025-04-11 eCollection Date: 2025-01-01 DOI:10.2147/JPR.S512989
Jiahui Lin, Zhilin Gu, Peng Zhou, Weikang Huang, Aihua Ou, Qi Zhao, Zhenhua Xu
{"title":"浅针治疗慢性颈部疼痛:一项多中心随机对照试验方案与功能磁共振成像和DTI。","authors":"Jiahui Lin, Zhilin Gu, Peng Zhou, Weikang Huang, Aihua Ou, Qi Zhao, Zhenhua Xu","doi":"10.2147/JPR.S512989","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to explore the central mechanisms of shallow acupuncture for chronic neck pain (CNP) using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), an innovative approach not commonly applied in shallow acupuncture research.</p><p><strong>Patients and methods: </strong>This multi-center randomized controlled trial will recruit 252 CNP patients from three centers (84 per center). Participants will be randomly assigned to three groups: shallow acupuncture, drug control (celecoxib capsules), or waiting list group, with 84 patients per group. The primary outcomes include total effective rate, visual analogue scale (VAS), Neck Disability Index (NDI), and brain imaging results (20 randomly selected patients per group). Secondary outcomes include the Self-Rating Anxiety Scale (SAS), Short Form 36 Questionnaire (SF-36), and cervical range of motion (CROM). Data will be collected at baseline, after 2 weeks, and at 3-month follow-up. fMRI and DTI data will be collected at baseline and after 2 weeks. Analyses will include regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), functional connectivity (FC), fractional anisotropy (FA), and mean diffusivity (MD) within and between groups. An additional 20 healthy volunteers will provide baseline fMRI and DTI data for comparison.</p><p><strong>Conclusion: </strong>This study will validate the clinical efficacy of shallow acupuncture for CNP and explore its central mechanisms using fMRI and DTI. The findings may provide neuroimaging evidence supporting the broader clinical application of shallow acupuncture in treating CNS-related diseases.</p>","PeriodicalId":16661,"journal":{"name":"Journal of Pain Research","volume":"18 ","pages":"1963-1973"},"PeriodicalIF":2.5000,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998947/pdf/","citationCount":"0","resultStr":"{\"title\":\"Shallow Acupuncture for Chronic Neck Pain: A Multicenter Randomized Controlled Trial Protocol with fMRI and DTI.\",\"authors\":\"Jiahui Lin, Zhilin Gu, Peng Zhou, Weikang Huang, Aihua Ou, Qi Zhao, Zhenhua Xu\",\"doi\":\"10.2147/JPR.S512989\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study aims to explore the central mechanisms of shallow acupuncture for chronic neck pain (CNP) using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), an innovative approach not commonly applied in shallow acupuncture research.</p><p><strong>Patients and methods: </strong>This multi-center randomized controlled trial will recruit 252 CNP patients from three centers (84 per center). Participants will be randomly assigned to three groups: shallow acupuncture, drug control (celecoxib capsules), or waiting list group, with 84 patients per group. The primary outcomes include total effective rate, visual analogue scale (VAS), Neck Disability Index (NDI), and brain imaging results (20 randomly selected patients per group). Secondary outcomes include the Self-Rating Anxiety Scale (SAS), Short Form 36 Questionnaire (SF-36), and cervical range of motion (CROM). Data will be collected at baseline, after 2 weeks, and at 3-month follow-up. fMRI and DTI data will be collected at baseline and after 2 weeks. Analyses will include regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), functional connectivity (FC), fractional anisotropy (FA), and mean diffusivity (MD) within and between groups. An additional 20 healthy volunteers will provide baseline fMRI and DTI data for comparison.</p><p><strong>Conclusion: </strong>This study will validate the clinical efficacy of shallow acupuncture for CNP and explore its central mechanisms using fMRI and DTI. The findings may provide neuroimaging evidence supporting the broader clinical application of shallow acupuncture in treating CNS-related diseases.</p>\",\"PeriodicalId\":16661,\"journal\":{\"name\":\"Journal of Pain Research\",\"volume\":\"18 \",\"pages\":\"1963-1973\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11998947/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pain Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/JPR.S512989\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pain Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/JPR.S512989","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

目的:利用功能磁共振成像(fMRI)和弥散张量成像(DTI)技术,探讨浅针治疗慢性颈痛(CNP)的核心机制,这是浅针研究中不常用的一种创新方法。患者和方法:该多中心随机对照试验将从三个中心招募252例CNP患者(每个中心84例)。参与者将被随机分配到三组:浅针灸,药物控制(塞来昔布胶囊),或等候名单组,每组84例患者。主要结局包括总有效率、视觉模拟评分(VAS)、颈部残疾指数(NDI)和脑成像结果(每组随机选择20例患者)。次要结果包括焦虑自评量表(SAS)、短表36问卷(SF-36)和颈椎活动度(CROM)。数据将在基线、2周后和3个月随访时收集。在基线和2周后收集fMRI和DTI数据。分析将包括区域均匀性(ReHo)、低频波动幅度(ALFF)、功能连通性(FC)、分数各向异性(FA)和组内和组间的平均扩散率(MD)。另外20名健康志愿者将提供fMRI和DTI基线数据进行比较。结论:本研究将通过fMRI和DTI验证浅针治疗CNP的临床疗效,并探讨其核心机制。研究结果可能为浅针治疗中枢相关疾病的临床应用提供神经影像学证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Shallow Acupuncture for Chronic Neck Pain: A Multicenter Randomized Controlled Trial Protocol with fMRI and DTI.

Purpose: This study aims to explore the central mechanisms of shallow acupuncture for chronic neck pain (CNP) using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), an innovative approach not commonly applied in shallow acupuncture research.

Patients and methods: This multi-center randomized controlled trial will recruit 252 CNP patients from three centers (84 per center). Participants will be randomly assigned to three groups: shallow acupuncture, drug control (celecoxib capsules), or waiting list group, with 84 patients per group. The primary outcomes include total effective rate, visual analogue scale (VAS), Neck Disability Index (NDI), and brain imaging results (20 randomly selected patients per group). Secondary outcomes include the Self-Rating Anxiety Scale (SAS), Short Form 36 Questionnaire (SF-36), and cervical range of motion (CROM). Data will be collected at baseline, after 2 weeks, and at 3-month follow-up. fMRI and DTI data will be collected at baseline and after 2 weeks. Analyses will include regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), functional connectivity (FC), fractional anisotropy (FA), and mean diffusivity (MD) within and between groups. An additional 20 healthy volunteers will provide baseline fMRI and DTI data for comparison.

Conclusion: This study will validate the clinical efficacy of shallow acupuncture for CNP and explore its central mechanisms using fMRI and DTI. The findings may provide neuroimaging evidence supporting the broader clinical application of shallow acupuncture in treating CNS-related diseases.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Pain Research
Journal of Pain Research CLINICAL NEUROLOGY-
CiteScore
4.50
自引率
3.70%
发文量
411
审稿时长
16 weeks
期刊介绍: Journal of Pain Research is an international, peer-reviewed, open access journal that welcomes laboratory and clinical findings in the fields of pain research and the prevention and management of pain. Original research, reviews, symposium reports, hypothesis formation and commentaries are all considered for publication. Additionally, the journal now welcomes the submission of pain-policy-related editorials and commentaries, particularly in regard to ethical, regulatory, forensic, and other legal issues in pain medicine, and to the education of pain practitioners and researchers.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信