注射后早期10分钟[18F]F-FAPI-42 uEXPLORER全身PET/CT扫描方案应用超迭代重建分期肺癌。

IF 1.3 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Hanyun Yang, Lijuan Wang, Ganghua Tang, Wenlan Zhou, Ying Tian, Yin Zhang, Yanchao Huang, Li Chen, Meng Wang, Yanjiang Han, Hubing Wu
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引用次数: 0

摘要

小转移灶的敏感检测,高度依赖于病灶的可视化,对肺癌的分期至关重要。我们研究了hyperiterative在早期18f标记成纤维细胞激活蛋白抑制剂(FAPI) PET/CT上改善肺癌小转移灶可视化的潜在益处。方法:对19例肺癌患者进行60分钟[18F]F-FAPI-42动态全身uEXPLORER PET/CT扫描。示踪剂注射后10分钟、30分钟和60分钟提取采集时间为5分钟的PET图像。采用有序子集期望最大化(OSEM)和超迭代法进行图像重建。计算两种重建方法及注射后10、30、60 min的SUVmax、肿瘤与肝比、肿瘤与血比、肿瘤与邻近非肿瘤比。结果:所有的HYPER和OSEM PET图像都是高质量的,其中HYPER PET图像清晰度更高。在所有时间点,HYPER PET比OSEM PET更清晰地描绘了小的阳性病灶(最大直径≤1 cm),特别是在注射后10分钟,其中16.4%的病灶在OSEM PET上表现不明显,但在HYPER PET上表现清晰。注射扫描后10、30、60 min的HYPER PET图像的肿瘤与肝比、肿瘤与血比、肿瘤与非肿瘤比均显著高于相应时间点的OSEM图像(P均≥0.05)。注射后10、30、60 min的OSEM和HYPER PET图像显示,大阳性病灶(最大直径1.0 cm)的SUVmax是小阳性病灶(最大直径≤1 cm)的2倍以上(所有比较P < 0.05)。重建方法和扫描次数对大的阳性病灶的可视化无明显影响。结论:与常规OSEM相比,HYPER迭代重建增强了肺癌小转移灶的可视化,在示踪剂注射后10分钟使用[18F]F-FAPI-42 uEXPLORER全身PET/CT进行有效的早期成像。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Early 10-Minute Postinjection [18F]F-FAPI-42 uEXPLORER Total-Body PET/CT Scanning Protocol for Staging Lung Cancer Using HYPER Iterative Reconstruction.

Sensitive detection of small metastatic lesions, which is highly dependent on lesion visualization, is crucial for staging lung cancer. We investigated the potential benefit of HYPER Iterative for improving the visualization of small metastatic lesions of lung cancer on early 18F-labeled fibroblast activation protein inhibitor (FAPI) PET/CT. Methods: A total of 19 patients with lung cancer underwent a 60-min [18F]F-FAPI-42 dynamic total-body uEXPLORER PET/CT scan. PET images with a 5-min acquisition time were extracted at 10, 30 min, and 60 min after tracer injection. Ordered-subset expectation maximization (OSEM) and HYPER Iterative were used for image reconstruction. SUVmax, tumor-to-liver ratio, tumor-to-blood ratio, and tumor-to-adjacent-nontumor ratio were calculated and compared between the 2 reconstruction methods and at 10, 30, and 60 min after injection. Results: All HYPER and OSEM PET images were of high quality, with HYPER PET images showing superior clarity. Small positive lesions (maximum diameter, ≤1 cm) were depicted clearer on HYPER PET than on OSEM PET images at all time points, particularly at 10 min after injection, where 16.4% of lesions were poorly visualized on OSEM PET but clearly depicted on HYPER PET images. The tumor-to-liver ratio, tumor-to-blood ratio, and tumor-to-nontumor ratio at 10, 30, and 60 min after injection scan on HYPER PET images were significantly higher than those on OSEM images at corresponding time points (P ≥ 0.05 for all comparisons). SUVmax was more than 2-fold greater in large positive lesions (maximum diameter, >1.0 cm) than in small positive lesions (maximum diameter, ≤1 cm) on both OSEM and HYPER PET images at 10, 30, and 60 min after injection (P < 0.05 for all comparisons). The visualization of large positive lesions was not significantly affected by reconstruction methods or scan times. Conclusion: HYPER Iterative reconstruction enhanced the visualization of small metastatic lesions in lung cancer when compared with conventional OSEM, enabling effective early imaging using [18F]F-FAPI-42 uEXPLORER total-body PET/CT at 10 min after tracer injection.

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来源期刊
Journal of nuclear medicine technology
Journal of nuclear medicine technology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
1.90
自引率
15.40%
发文量
57
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