HIV-1逆转录酶亚型显示CRF35-AD是伊朗东北部的一种当前亚型。

IF 1 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Biology Research Communications Pub Date : 2025-01-01 DOI:10.22099/mbrc.2025.52193.2089

Zahra Mazaheri, Masoud Youssefi

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引用次数: 0

摘要

此前，研究人员分析了HIV-1逆转录酶基因的序列，以确定与耐药性相关的突变。我们统计分析了一组附加数据与突变增加之间的关系。现有序列也进行了系统发育分析。在所有进行系统发育树分析的患者中，1人患有F亚型，2人患有CRF01-AE菌株，2人患有A亚型。系统进化树分析显示，HIV-1 CRF35-AD是研究病例中最常见的亚型（88.6%）。治疗中断次数（r=0.621, df=20, p=0.002）和治疗持续时间（r=0.452, df=20, p=0.035）与突变增加显著相关。

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HIV-1 reverse transcriptase subtyping revealed CRF35-AD as a current subtype in the northeast of Iran.

Previously, the sequence of the HIV-1 reverse transcriptase gene was analyzed to identify mutations associated with drug resistance. We statistically analyzed the relationship between a set of additional data and increasing mutations. Existing sequences were also phylogenetically analyzed. Of all patients tested for phylogenetic tree analysis, one individual had the F subtype, two had the CRF01-AE strain, and two had the A subtype. Phylogenetic tree analysis revealed that HIV-1 CRF35-AD was the most prevalent subtype (88.6%) among the cases studied. The number of treatment discontinuations (r=0.621, df=20, p=0.002) and the duration of treatment (r=0.452, df=20, p=0.035) were significantly correlated with an increase in mutations.

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来源期刊

Molecular Biology Research Communications BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： “Molecular Biology Research Communications” (MBRC) is an international journal of Molecular Biology. It is published quarterly by Shiraz University (Iran). The MBRC is a fully peer-reviewed journal. The journal welcomes submission of Original articles, Short communications, Invited review articles, and Letters to the Editor which meets the general criteria of significance and scientific excellence in all fields of “Molecular Biology”.