Cemal Kazezoglu, Arzu İrvem, Yasemin Tuba Sutasir, Büşra Çakiroglu, Banu Kirgiz, Habip Yilmaz, Ali Kocatas
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Also, it was aimed to investigate the neuroinhibitory Gamma-Aminobutyric acid (GABA) levels in order to examine the physiopathology.</p><p><strong>Materials and methods: </strong>Thirty adult cases who were followed up in the infection clinic with positive SARS CoV 2 RT-PCR and diagnosed with COVID 19 disease were included in the study with consent. The amino acid profile of these patients' urine samples, 30 different amino acid levels and creatine levels were examined using the liquid chromatography-mass spectrometry (LCMS) method on the SCIEX QTRAP 4500 device.</p><p><strong>Results: </strong>The mean age of the patients is 40 ± 5. Elevated GABA in 28/30 cases, high hydroxylysine amino acid in 27/30 cases, low glycine in 30/30 cases were detected in the urine. The creatinine levels of the patients were found to be normal.</p><p><strong>Conclusion: </strong>It has been thought that the height of GABA may be due to bacteria producing GABA as a result of the change in microbiota due to lactic acidosis, as well as that the virus may directly affect the brain and cause an increase in GABA.</p>","PeriodicalId":14633,"journal":{"name":"Iranian Journal of Microbiology","volume":"17 1","pages":"122-127"},"PeriodicalIF":1.7000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049756/pdf/","citationCount":"0","resultStr":"{\"title\":\"Urine amino acid and gamma aminobutyric acid level in COVID 19 patients.\",\"authors\":\"Cemal Kazezoglu, Arzu İrvem, Yasemin Tuba Sutasir, Büşra Çakiroglu, Banu Kirgiz, Habip Yilmaz, Ali Kocatas\",\"doi\":\"10.18502/ijm.v17i1.17809\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background and objectives: </strong>SARS CoV2 has tropism for various tissues, including the respiratory tract, brain, endothelium, heart, kidney and liver. Neurological symptoms can also be seen in the clinical course of the disease, and anosmia is the most common. The main objective of our study was to examine the urinary amino acid profiles of moderately severe patients diagnosed with COVID-19 with a positive RT-PCR test and try to find metabolic changes associated with the infection. Also, it was aimed to investigate the neuroinhibitory Gamma-Aminobutyric acid (GABA) levels in order to examine the physiopathology.</p><p><strong>Materials and methods: </strong>Thirty adult cases who were followed up in the infection clinic with positive SARS CoV 2 RT-PCR and diagnosed with COVID 19 disease were included in the study with consent. The amino acid profile of these patients' urine samples, 30 different amino acid levels and creatine levels were examined using the liquid chromatography-mass spectrometry (LCMS) method on the SCIEX QTRAP 4500 device.</p><p><strong>Results: </strong>The mean age of the patients is 40 ± 5. Elevated GABA in 28/30 cases, high hydroxylysine amino acid in 27/30 cases, low glycine in 30/30 cases were detected in the urine. The creatinine levels of the patients were found to be normal.</p><p><strong>Conclusion: </strong>It has been thought that the height of GABA may be due to bacteria producing GABA as a result of the change in microbiota due to lactic acidosis, as well as that the virus may directly affect the brain and cause an increase in GABA.</p>\",\"PeriodicalId\":14633,\"journal\":{\"name\":\"Iranian Journal of Microbiology\",\"volume\":\"17 1\",\"pages\":\"122-127\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049756/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Iranian Journal of Microbiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18502/ijm.v17i1.17809\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Iranian Journal of Microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18502/ijm.v17i1.17809","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Urine amino acid and gamma aminobutyric acid level in COVID 19 patients.
Background and objectives: SARS CoV2 has tropism for various tissues, including the respiratory tract, brain, endothelium, heart, kidney and liver. Neurological symptoms can also be seen in the clinical course of the disease, and anosmia is the most common. The main objective of our study was to examine the urinary amino acid profiles of moderately severe patients diagnosed with COVID-19 with a positive RT-PCR test and try to find metabolic changes associated with the infection. Also, it was aimed to investigate the neuroinhibitory Gamma-Aminobutyric acid (GABA) levels in order to examine the physiopathology.
Materials and methods: Thirty adult cases who were followed up in the infection clinic with positive SARS CoV 2 RT-PCR and diagnosed with COVID 19 disease were included in the study with consent. The amino acid profile of these patients' urine samples, 30 different amino acid levels and creatine levels were examined using the liquid chromatography-mass spectrometry (LCMS) method on the SCIEX QTRAP 4500 device.
Results: The mean age of the patients is 40 ± 5. Elevated GABA in 28/30 cases, high hydroxylysine amino acid in 27/30 cases, low glycine in 30/30 cases were detected in the urine. The creatinine levels of the patients were found to be normal.
Conclusion: It has been thought that the height of GABA may be due to bacteria producing GABA as a result of the change in microbiota due to lactic acidosis, as well as that the virus may directly affect the brain and cause an increase in GABA.
期刊介绍：
The Iranian Journal of Microbiology (IJM) is an international, multi-disciplinary, peer-reviewed journal that provides rapid publication of the most advanced scientific research in the areas of basic and applied research on bacteria and other micro-organisms, including bacteria, viruses, yeasts, fungi, microalgae, and protozoa concerning the development of tools for diagnosis and disease control, epidemiology, antimicrobial agents, clinical microbiology, immunology, Genetics, Genomics and Molecular Biology. Contributions may be in the form of original research papers, review articles, short communications, case reports, technical reports, and letters to the Editor. Research findings must be novel and the original data must be available for review by the Editors, if necessary. Studies that are preliminary, of weak originality or merely descriptive as well as negative results are not appropriate for the journal. Papers considered for publication must be unpublished work (except in an abstract form) that is not under consideration for publication anywhere else, and all co-authors should have agreed to the submission. Manuscripts should be written in English.
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