快速治愈的硫酸软骨素锌@甲基丙烯酸透明质酸水凝胶:一种为紧急伤口管理量身定制的新型光固化生物材料。

Shiman Li, Qili Sun, Huicheng Cao, Chunan Lu, Jialin Yu, Kangyu Chen, Chuqing Tang, Zimo Li, Shuaishuai Cao, Tenghui Zeng, Bin Tang
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引用次数: 0

摘要

在当今的急诊医疗领域,快速止血和伤口愈合技术是至关重要的。然而,传统方法虽然有效,但存在止血缓慢、易感染、不适合不规则伤口等局限性。为了解决这些问题,本研究将甲基丙烯酸透明质酸(HAMA)与硫酸软骨素锌(CSZn)结合,成功开发了一种新型的可喷涂光固化水凝胶CSZn@HAMA。材料表征证实,CSZn被有效加载到HAMA中,同时保留了HAMA的光固化和可喷涂性能。这使得CSZn@HAMA水凝胶在喷涂后迅速固化并在伤口上形成紧密的保护膜。进一步的细胞实验表明,该水凝胶具有显著的抗炎作用,并能有效促进胶原蛋白的生成和血管生成。因此,CSZn@HAMA已成为一种有前途的生物材料,用于紧急医疗护理中的伤口管理。 。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Rapidly curable zinc chondroitin sulfate @ methacrylated hyaluronic acid hydrogel: a novel photocurable biomaterial tailored for emergency wound management.

In today's emergency medical field, rapid hemostasis and wound healing technologies are of paramount importance. However, traditional methods, although effective, have limitations such as slow hemostasis, susceptibility to infection, and unsuitability for irregular wounds. To address these issues, this study combined methacrylated hyaluronic acid (HAMA) with zinc chondroitin sulfate (CSZn) to successfully develop a novel sprayable photocurable hydrogel, CSZn@HAMA. Material characterization confirmed that CSZn was effectively loaded into HAMA, while retaining HAMA's photocurable and sprayable properties. This allows the CSZn@HAMA hydrogel to rapidly solidify and form a tight protective film over the wound after spraying. Further cell experiments demonstrated that this hydrogel has significant anti-inflammatory effects and can effectively promote collagen production and angiogenesis. Therefore, CSZn@HAMA has emerged as a promising biomaterial for wound management in emergency medical care.

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