黄花蒿具有潜在抗炎活性的化学成分。

IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED
Qi-Guo Wu, Si-Meng Li, Ye-Qing Hu, Fu Cao, Yong-Li Wang, Gui-Xin Chou
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引用次数: 0

摘要

对黄花蒿的植物化学分析发现了3种新的木脂素苷类化合物(arteannuoside A-B, annusesquilignanoside)和18种已知化合物(4-21),包括跨大木脂素(4-13)、香豆素(14)、含氮化合物(15)、苯乙醇糖苷(16)和酚类化合物(17-21)。化合物(4、6、10、12、15-18)均为首次从该植物中分离得到。结构表征采用核磁共振波谱和文献比较。新化合物在lps活化的巨噬细胞中表现出浓度依赖性的IL-6抑制作用。在100 μM时,化合物1(68.75%)、2(71.89%)和3(61.34%)表现出较强的抑制活性,而在50 μM时,化合物1的抑制率分别为33.45%、39.37%和45.36%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chemical constituents from artemisia annua with potential anti-inflammatory activities.

Phytochemical analysis of Artemisia annua aerial parts revealed three novel lignan glycosides (arteannuoside A-B, annusesquilignanoside) and 18 known compounds (4-21), including spanning megastigmanes (4-13), coumarin (14), nitrogen-containing compound (15), phenylethanol glycoside (16), and phenolic compounds (17-21). Compounds (4, 6, 10, 12, 15-18) were first isolated from this species. Structural characterization employed NMR spectroscopy and literature comparison. The new compounds demonstrated concentration-dependent IL-6 inhibition in LPS-activated macrophages. At 100 μM, compounds 1 (68.75%), 2 (71.89%) and 3 (61.34%) showed strong activity, while at 50 μM yielded 33.45%, 39.37%, and 45.36% inhibition respectively.

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来源期刊
CiteScore
3.20
自引率
5.90%
发文量
47
审稿时长
2.3 months
期刊介绍: The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.
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