{"title":"黄花蒿具有潜在抗炎活性的化学成分。","authors":"Qi-Guo Wu, Si-Meng Li, Ye-Qing Hu, Fu Cao, Yong-Li Wang, Gui-Xin Chou","doi":"10.1080/10286020.2025.2490115","DOIUrl":null,"url":null,"abstract":"<p><p>Phytochemical analysis of <i>Artemisia annua</i> aerial parts revealed three novel lignan glycosides (arteannuoside A-B, annusesquilignanoside) and 18 known compounds (<b>4</b>-<b>21</b>), including spanning megastigmanes (<b>4-13</b>), coumarin (<b>14</b>), nitrogen-containing compound (<b>15</b>), phenylethanol glycoside (<b>16</b>), and phenolic compounds (<b>17</b>-<b>21</b>). Compounds (<b>4, 6, 10, 12, 15-18)</b> were first isolated from this species. Structural characterization employed NMR spectroscopy and literature comparison. The new compounds demonstrated concentration-dependent IL-6 inhibition in LPS-activated macrophages. At 100 μM, compounds <b>1</b> (68.75%), <b>2</b> (71.89%) and <b>3</b> (61.34%) showed strong activity, while at 50 μM yielded 33.45%, 39.37%, and 45.36% inhibition respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.3000,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Chemical constituents from <i>artemisia annua</i> with potential anti-inflammatory activities.\",\"authors\":\"Qi-Guo Wu, Si-Meng Li, Ye-Qing Hu, Fu Cao, Yong-Li Wang, Gui-Xin Chou\",\"doi\":\"10.1080/10286020.2025.2490115\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Phytochemical analysis of <i>Artemisia annua</i> aerial parts revealed three novel lignan glycosides (arteannuoside A-B, annusesquilignanoside) and 18 known compounds (<b>4</b>-<b>21</b>), including spanning megastigmanes (<b>4-13</b>), coumarin (<b>14</b>), nitrogen-containing compound (<b>15</b>), phenylethanol glycoside (<b>16</b>), and phenolic compounds (<b>17</b>-<b>21</b>). Compounds (<b>4, 6, 10, 12, 15-18)</b> were first isolated from this species. Structural characterization employed NMR spectroscopy and literature comparison. The new compounds demonstrated concentration-dependent IL-6 inhibition in LPS-activated macrophages. At 100 μM, compounds <b>1</b> (68.75%), <b>2</b> (71.89%) and <b>3</b> (61.34%) showed strong activity, while at 50 μM yielded 33.45%, 39.37%, and 45.36% inhibition respectively.</p>\",\"PeriodicalId\":15180,\"journal\":{\"name\":\"Journal of Asian Natural Products Research\",\"volume\":\" \",\"pages\":\"1-12\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-04-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Asian Natural Products Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/10286020.2025.2490115\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Asian Natural Products Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/10286020.2025.2490115","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Chemical constituents from artemisia annua with potential anti-inflammatory activities.
Phytochemical analysis of Artemisia annua aerial parts revealed three novel lignan glycosides (arteannuoside A-B, annusesquilignanoside) and 18 known compounds (4-21), including spanning megastigmanes (4-13), coumarin (14), nitrogen-containing compound (15), phenylethanol glycoside (16), and phenolic compounds (17-21). Compounds (4, 6, 10, 12, 15-18) were first isolated from this species. Structural characterization employed NMR spectroscopy and literature comparison. The new compounds demonstrated concentration-dependent IL-6 inhibition in LPS-activated macrophages. At 100 μM, compounds 1 (68.75%), 2 (71.89%) and 3 (61.34%) showed strong activity, while at 50 μM yielded 33.45%, 39.37%, and 45.36% inhibition respectively.
期刊介绍:
The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures.
All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.