HLA-C*01:02和-C*04:03可能与中国汉族梅毒螺旋体感染易感性有关

IF 2.3 4区 医学 Q3 GENETICS & HEREDITY
Chen Chen, Fang Wang, Nanying Chen, Lina Dong, Wei Zhang, Ji He, Faming Zhu
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引用次数: 0

摘要

梅毒螺旋体(TP)易感性与人类白细胞抗原(HLA)低分辨率位点之间的一些关联已被报道。然而,TP感染和HLA等位基因的高分辨率数据是有限的。本研究的目的是对中国汉族人群中具有TP易感性的HLA等位基因进行高分辨率筛选。本研究共纳入184例TP感染者,并将254例无血缘关系的健康献血者作为对照组。采用下一代测序(NGS)技术对样本进行HLA-A、-C、-B、-DRB1、-DQB1和-DPB1位点的基因分型。统计分析TP感染与HLA基因座等位基因和单倍型的相关性。HLA- a *32:01 (0.00% vs. 1.57%, p = 0.024)、-B*52:01 (1.36% vs. 4.13%, p = 0.025)、-C*01:02 (22.55% vs. 16.54%, p = 0.029)、-C*04:03 (1.63% vs. 0.2%, p = 0.046)和-DQB1*05:03 (1.63% vs. 4.13%, p = 0.046) 5个HLA等位基因与TP感染存在潜在关联。但经p值校正后无显著性差异。对照组HLA-A*33:03-C*03:02-B*58:01-DRB1*03:01-DQB1*02:01-DPB1*05:01单倍型出现频率高于TP感染组(p = 0.002)。相比之下,对照组的HLA-A*02:07-C*01:02-B*46:01-DRB1*08:03-DQB1*06:01-DPB1*02:01、HLA-A*11:01-C*03:04-B*13:01-DRB1*09:01-DQB1*03:03-DPB1*05:01、HLA-A*11:01-C*07:02-B* 06:01-DPB1*02:01和HLA-A*30:01-C*06:02-B*13:02-DRB1*07:01-DQB1*02:02-DPB1*02:01单倍型的频率低于TP感染组(p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HLA-C*01:02 and -C*04:03 May Confer Susceptibility to Treponema pallidum Infection in the Chinese Han Population.

Some associations between Treponema pallidum (TP) susceptibility and human leukocyte antigen (HLA) loci at low resolution have been reported. However, the data for TP infection and HLA alleles at high resolution are limited. The purpose of this study was to perform a high-resolution screen for HLA alleles that confer susceptibility to TP infection in the Chinese Han population. A total of 184 individuals with TP infection were included in the study, and 254 unrelated healthy blood donors were included in the control group. The samples were genotyped for the HLA-A, -C, -B, -DRB1, -DQB1 and -DPB1 loci using next-generation sequencing (NGS) technology. The correlations between TP infection and the alleles and haplotypes of HLA loci were determined by statistical analysis. Five HLA alleles, including HLA-A*32:01 (0.00% vs. 1.57%, p = 0.024), -B*52:01 (1.36% vs. 4.13%, p = 0.025), -C*01:02 (22.55% vs. 16.54%, p = 0.029), -C*04:03 (1.63% vs. 0.2%, p = 0.046) and -DQB1*05:03 (1.63% vs. 4.13%, p = 0.046), are potentially associated with TP infection. However, no significant difference was detected after p value correction. The frequency of the HLA-A*33:03-C*03:02-B*58:01-DRB1*03:01-DQB1*02:01-DPB1*05:01 haplotype in the control group was greater than that in the TP infection group (p = 0.002). In contrast, the frequency of the HLA-A*02:07-C*01:02-B*46:01-DRB1*08:03-DQB1*06:01-DPB1*02:01, HLA-A*11:01-C*03:04-B*13:01-DRB1*09:01-DQB1*03:03-DPB1*05:01, HLA-A*11:01-C*07:02-B*40:01-DRB1*08:03-DQB1*06:01-DPB1*02:01 and HLA-A*30:01-C*06:02-B*13:02-DRB1*07:01-DQB1*02:02-DPB1*02:01 haplotypes were lower in the control group than in the TP infection group (p < 0.05). HLA-C*01:02 and -C*04:03 may confer susceptibility to TP infection, whereas A*32:01, -B*52:01 and -DQB1*05:03 may protect against TP infection. These data are helpful in preventing and controlling TP transmission.

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来源期刊
CiteScore
4.70
自引率
0.00%
发文量
48
审稿时长
6-12 weeks
期刊介绍: The International Journal of Immunogenetics (formerly European Journal of Immunogenetics) publishes original contributions on the genetic control of components of the immune system and their interactions in both humans and experimental animals. The term ''genetic'' is taken in its broadest sense to include studies at the evolutionary, molecular, chromosomal functional and population levels in both health and disease. Examples are: -studies of blood groups and other surface antigens- cell interactions and immune response- receptors, antibodies, complement components and cytokines- polymorphism- evolution of the organisation, control and function of immune system components- anthropology and disease associations- the genetics of immune-related disease: allergy, autoimmunity, immunodeficiency and other immune pathologies- All papers are seen by at least two independent referees and only papers of the highest quality are accepted.
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