点扫描质子束治疗无法手术的肝细胞癌：初步结果。

IF 1.8 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

In vivo Pub Date : 2025-05-01 DOI:10.21873/invivo.13966

Yutaka Fujimoto, Sachika Shiraishi, Masashi Yamanaka, Akihiro Yamano, Kazuki Matsumoto, Shintaro Shiba, Toshitaka Tsukiyama, Masahiro Kobayashi, Koichi Tokuuye

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引用次数: 0

摘要

背景/目的：点扫描质子束治疗（SS-PBT）用于治疗手术无法进入的肝细胞癌，主要受呼吸运动的影响。患者和方法：在2022年10月至2023年12月期间，本研究纳入了12例患者，以评估SS-PBT的疗效。中位随访时间为13.1个月。结果：1年生存率、无进展生存率和局部控制率分别为79.5%、57.1%和100%，无2级及以上pbt相关毒性。这12名患者的临床结果似乎与日本质子中心进行的前瞻性研究的数据相当。结论：SS-PBT有望成为手术无法治疗的肝细胞癌的一种治疗选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Spot Scanning Proton Beam Therapy for Surgery-inaccessible Hepatocellular Carcinoma: Preliminary Results.

Background/aim: Spot scanning proton beam therapy (SS-PBT) was employed for the treatment of surgery-inaccessible hepatocellular carcinoma, primarily influenced by respiratory movement.

Patients and methods: Between October 2022 and December 2023, 12 patients were enrolled in this study to evaluate the efficacy of SS-PBT. The median follow-up time was 13.1 months.

Results: The one-year survival, progression-free survival, and local control rates were 79.5%, 57.1%, and 100%, respectively, without grade 2 or higher PBT-related toxicities. The clinical outcomes of these 12 patients appear comparable to data from prospective studies conducted at proton centers across Japan.

Conclusion: SS-PBT shows promise as a treatment option for surgery-inaccessible hepatocellular carcinoma.

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来源期刊

In vivo 医学-医学：研究与实验

CiteScore

4.20

自引率

4.30%

发文量

330

审稿时长

3-8 weeks

期刊介绍： IN VIVO is an international peer-reviewed journal designed to bring together original high quality works and reviews on experimental and clinical biomedical research within the frames of physiology, pathology and disease management. The topics of IN VIVO include: 1. Experimental development and application of new diagnostic and therapeutic procedures; 2. Pharmacological and toxicological evaluation of new drugs, drug combinations and drug delivery systems; 3. Clinical trials; 4. Development and characterization of models of biomedical research; 5. Cancer diagnosis and treatment; 6. Immunotherapy and vaccines; 7. Radiotherapy, Imaging; 8. Tissue engineering, Regenerative medicine; 9. Carcinogenesis.