美国女性避孕药使用时间与抑郁症风险之间的关系:一项横断面NHANES研究。

IF 1.3 4区 医学 Q4 PSYCHIATRY
Yajing Sun, Chen Zhang
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引用次数: 0

摘要

目的探讨美国女性避孕药使用时间(DBCPU)与抑郁症状风险的关系。方法采用多元logistic回归模型、拟合平滑曲线、亚组和阈值分析,分析2005-2012年美国国家健康与营养调查4996名女性的数据,以评估DBCPU与抑郁症状的相关性。结果两组患者DBCPU、月经初潮年龄、年龄分层、种族、婚姻状况差异均有统计学意义(P < 0.05)。调整后的加权logistic回归模型显示DBCPU与抑郁症状呈负相关。亚组分析显示,这种关联在没有糖尿病的女性中更为明显。限制三次样条图显示,随着DBCPU的增加,抑郁症状的风险降低。阈值效应分析确定了9.3为拐点,低于该值的风险降低更为显著(优势比0.94[95%置信区间0.90-0.98];P = 0.006)。结论长期口服避孕药可能是预防和治疗女性抑郁症的有效干预策略;然而,需要进一步的前瞻性研究来证实这一假设。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between duration of birth control pill use and risk of depression among US women.

ObjectiveTo explore the association between the duration of birth control pill use (DBCPU) and the risk for depressive symptoms among women in the United States.MethodCross-sectional data from 4996 American women obtained from the National Health and Nutrition Examination Survey, 2005-2012, were analyzed to evaluate the association between DBCPU and depressive symptoms using multivariate logistic regression models, fitted smooth curves, and subgroup and threshold analyses.ResultsStatistically significant differences (P < 0.05) were found for DBCPU, age at menarche, age stratification, race, and marital status. The adjusted weighted logistic regression model revealed a negative correlation between DBCPU and depressive symptoms. Subgroup analysis revealed that this association was stronger among women without diabetes. The restricted cubic splines plot indicated that the risk for depressive symptoms decreased as DBCPU increased. Threshold effect analysis identified an inflection point at 9.3, with a more significant risk reduction below this value (odds ratio 0.94 [95% confidence interval 0.90-0.98]; P = 0.006).ConclusionLong-term oral contraceptive use may be an effective intervention strategy for the prevention and treatment of depression in women; however, further prospective studies are needed to confirm this hypothesis.

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来源期刊
CiteScore
3.00
自引率
5.00%
发文量
55
审稿时长
6-12 weeks
期刊介绍: The International Journal of Psychiatry in Medicine (IJPM) bridges the gap between clinical psychiatry research and primary care clinical research. Providing a forum for addressing: The relevance of psychobiological, psychological, social, familial, religious, and cultural factors in the development and treatment of illness; the relationship of biomarkers to psychiatric symptoms and syndromes in primary care...
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