{"title":"美国女性避孕药使用时间与抑郁症风险之间的关系:一项横断面NHANES研究。","authors":"Yajing Sun, Chen Zhang","doi":"10.1177/00912174251334309","DOIUrl":null,"url":null,"abstract":"<p><p>ObjectiveTo explore the association between the duration of birth control pill use (DBCPU) and the risk for depressive symptoms among women in the United States.MethodCross-sectional data from 4996 American women obtained from the National Health and Nutrition Examination Survey, 2005-2012, were analyzed to evaluate the association between DBCPU and depressive symptoms using multivariate logistic regression models, fitted smooth curves, and subgroup and threshold analyses.ResultsStatistically significant differences (<i>P</i> < 0.05) were found for DBCPU, age at menarche, age stratification, race, and marital status. The adjusted weighted logistic regression model revealed a negative correlation between DBCPU and depressive symptoms. Subgroup analysis revealed that this association was stronger among women without diabetes. The restricted cubic splines plot indicated that the risk for depressive symptoms decreased as DBCPU increased. Threshold effect analysis identified an inflection point at 9.3, with a more significant risk reduction below this value (odds ratio 0.94 [95% confidence interval 0.90-0.98]; <i>P</i> = 0.006).ConclusionLong-term oral contraceptive use may be an effective intervention strategy for the prevention and treatment of depression in women; however, further prospective studies are needed to confirm this hypothesis.</p>","PeriodicalId":50294,"journal":{"name":"International Journal of Psychiatry in Medicine","volume":" ","pages":"637-647"},"PeriodicalIF":1.3000,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between duration of birth control pill use and risk of depression among US women.\",\"authors\":\"Yajing Sun, Chen Zhang\",\"doi\":\"10.1177/00912174251334309\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>ObjectiveTo explore the association between the duration of birth control pill use (DBCPU) and the risk for depressive symptoms among women in the United States.MethodCross-sectional data from 4996 American women obtained from the National Health and Nutrition Examination Survey, 2005-2012, were analyzed to evaluate the association between DBCPU and depressive symptoms using multivariate logistic regression models, fitted smooth curves, and subgroup and threshold analyses.ResultsStatistically significant differences (<i>P</i> < 0.05) were found for DBCPU, age at menarche, age stratification, race, and marital status. The adjusted weighted logistic regression model revealed a negative correlation between DBCPU and depressive symptoms. Subgroup analysis revealed that this association was stronger among women without diabetes. The restricted cubic splines plot indicated that the risk for depressive symptoms decreased as DBCPU increased. Threshold effect analysis identified an inflection point at 9.3, with a more significant risk reduction below this value (odds ratio 0.94 [95% confidence interval 0.90-0.98]; <i>P</i> = 0.006).ConclusionLong-term oral contraceptive use may be an effective intervention strategy for the prevention and treatment of depression in women; however, further prospective studies are needed to confirm this hypothesis.</p>\",\"PeriodicalId\":50294,\"journal\":{\"name\":\"International Journal of Psychiatry in Medicine\",\"volume\":\" \",\"pages\":\"637-647\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Psychiatry in Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/00912174251334309\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/10 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Psychiatry in Medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/00912174251334309","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/10 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Association between duration of birth control pill use and risk of depression among US women.
ObjectiveTo explore the association between the duration of birth control pill use (DBCPU) and the risk for depressive symptoms among women in the United States.MethodCross-sectional data from 4996 American women obtained from the National Health and Nutrition Examination Survey, 2005-2012, were analyzed to evaluate the association between DBCPU and depressive symptoms using multivariate logistic regression models, fitted smooth curves, and subgroup and threshold analyses.ResultsStatistically significant differences (P < 0.05) were found for DBCPU, age at menarche, age stratification, race, and marital status. The adjusted weighted logistic regression model revealed a negative correlation between DBCPU and depressive symptoms. Subgroup analysis revealed that this association was stronger among women without diabetes. The restricted cubic splines plot indicated that the risk for depressive symptoms decreased as DBCPU increased. Threshold effect analysis identified an inflection point at 9.3, with a more significant risk reduction below this value (odds ratio 0.94 [95% confidence interval 0.90-0.98]; P = 0.006).ConclusionLong-term oral contraceptive use may be an effective intervention strategy for the prevention and treatment of depression in women; however, further prospective studies are needed to confirm this hypothesis.
期刊介绍:
The International Journal of Psychiatry in Medicine (IJPM) bridges the gap between clinical psychiatry research and primary care clinical research. Providing a forum for addressing: The relevance of psychobiological, psychological, social, familial, religious, and cultural factors in the development and treatment of illness; the relationship of biomarkers to psychiatric symptoms and syndromes in primary care...