目前Tau PET成像在神经变性中的作用。

IF 4.6 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Seminars in nuclear medicine Pub Date : 2025-07-01 DOI:10.1053/j.semnuclmed.2025.03.002

Greet Vanderlinden , Rik Vandenberghe , Mathieu Vandenbulcke , Koen Van Laere

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引用次数: 0

摘要

神经退行性tau病的特点是病理过度磷酸化的tau蛋白，随后形成聚集体。Tau PET示踪剂具有结合这些病理性Tau聚集体的亲和力，已被开发用于测量疾病进展并支持治疗药物开发。在这篇综述中，我们总结了神经退行性tau病变的病理生理学。我们概述了可用的第一代和第二代tau PET示踪剂，重点介绍了新的tau PET示踪剂的发展，并讨论了tau PET图像的量化。接下来，我们总结了tau PET与脑脊液和血浆tau生物标志物的关系。最后，我们回顾了目前关于tau PET与液体tau生物标志物在诊断、预后和治疗发展方面的临床应用的建议。

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The Current Role of Tau PET Imaging in Neurodegeneration

Neurodegenerative tauopathies are characterized by the pathological hyperphosphorylation of tau proteins that subsequently form aggregates. Tau PET tracers with affinity to bind these pathological tau aggregates have been developed to measure disease progression and to support therapeutic drug development. In this review, we summarize the pathophysiology of tau throughout the range of neurodegenerative tauopathies. We outline the available first- and second-generation tau PET tracers, with a focus on new tau PET tracer developments, and discuss the quantification of tau PET images. Next, we summarize how tau PET relates to cerebrospinal fluid and plasma tau biomarkers. Finally, we review the current recommendations on the clinical use of tau PET versus fluid tau biomarkers in diagnosis, prognosis and treatment development.

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来源期刊

Seminars in nuclear medicine 医学-核医学

CiteScore

9.80

自引率

6.10%

发文量

审稿时长

14 days

期刊介绍： Seminars in Nuclear Medicine is the leading review journal in nuclear medicine. Each issue brings you expert reviews and commentary on a single topic as selected by the Editors. The journal contains extensive coverage of the field of nuclear medicine, including PET, SPECT, and other molecular imaging studies, and related imaging studies. Full-color illustrations are used throughout to highlight important findings. Seminars is included in PubMed/Medline, Thomson/ISI, and other major scientific indexes.