精神病学治疗用致幻剂的设置和设置:系统回顾。

IF 4.5 3区 医学 Q1 CLINICAL NEUROLOGY
Clémentine Estric, Thomas Duron, Sarah Kabani, Jorge Lopez-Castroman
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引用次数: 0

摘要

致幻剂在精神病学上提供了有希望的结果。然而,参与者的准备(设置)和服用迷幻药的环境条件(设置)并没有标准化。我们描述的设置和设置的治疗使用致幻剂的人与精神障碍。在本系统综述中,文章在PubMed和Web of Science数据库中被识别,截止日期为2023年12月12日。只有用英语或法语发表的临床试验才有资格,使用致幻剂戒断的研究被排除在外。16个领域的设置和设置进行了评估,包括参与者选择,会前和会后干预,监测存在,环境管理和会议结束程序。在筛选的4912篇文章中,保留了27篇报道25项研究的文章。纳入的研究中有13项是随机试验,12项是开放标签研究,共有763名参与者。研究在不同程度上考虑了set和setting的特征。参与者的选择和安全环境的创造始终存在,但文章在报告监控培训(52%),控制视觉干扰(64%)和创造愉快的环境(68%)方面更为多样化。裸盖菇素的比例过高(47%)。每个研究都描述了许多关键因素,但设置和设置的差异限制了可比性和可重复性。协调这些方面将有助于解释未来的研究,并有助于理解致幻剂在精神病学中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Set and setting of psychedelics for therapeutic use in psychiatry: A systematic review.

Psychedelics offer promising outcomes in psychiatry. However, the preparation of participants (set) and the environmental conditions of taking a psychedelic (setting) are not standardized. We describe the set and setting for therapeutic use of psychedelic drugs in people with psychiatric disorders. In this systematic review, articles were identified in the PubMed and Web of Science databases until 12 December 2023. Only clinical trials published in English or French were eligible, and studies using psychedelics for withdrawal were excluded. Sixteen domains of set and setting were assessed covering participant selection, pre- and post-session interventions, monitor presence, environmental management, and end-of-session procedure. Of 4912 articles screened, 27 articles were retained reporting on 25 studies. Thirteen of the included studies reported randomized trials, while 12 were open-label studies, on a total of 763 participants. Studies considered features of set and setting to different extents. Participant selection and the creation of a safe environment were consistently present, but articles were more heterogeneous about reporting monitor training (52%), controlling visual distractors (64%) and creating a pleasant environment (68%). Psilocybin was over-represented (47%). Many key elements were described in each study, but differences in set and setting limit comparability and reproducibility. Harmonizing these aspects would aid the interpretation of future studies and help understand the effect of psychedelics in psychiatry.

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来源期刊
Journal of Psychopharmacology
Journal of Psychopharmacology 医学-精神病学
CiteScore
8.60
自引率
4.90%
发文量
126
审稿时长
3-8 weeks
期刊介绍: The Journal of Psychopharmacology is a fully peer-reviewed, international journal that publishes original research and review articles on preclinical and clinical aspects of psychopharmacology. The journal provides an essential forum for researchers and practicing clinicians on the effects of drugs on animal and human behavior, and the mechanisms underlying these effects. The Journal of Psychopharmacology is truly international in scope and readership.
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