J Ray Runyon, Mohammad Dehghan Rouzi, Myeounggon Lee, Cole Babbitt, David W Tano, Diezel Cochenour, Esther M Sternberg, Terrill Yuhas, Lisa White, Bijan Najafi, Bonnie J LaFleur
{"title":"解码精确老化：认知衰退、脆弱和激素生物标志物的交集。","authors":"J Ray Runyon, Mohammad Dehghan Rouzi, Myeounggon Lee, Cole Babbitt, David W Tano, Diezel Cochenour, Esther M Sternberg, Terrill Yuhas, Lisa White, Bijan Najafi, Bonnie J LaFleur","doi":"10.1159/000546250","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cognitive frailty, characterized by the coexistence of cognitive impairment and physical frailty, is a significant predictor of cognitive decline. However, few studies integrate both cognitive and physical assessments alongside hormonal markers, such as cortisol, that may influence frailty and cognitive function. To address this gap, our study combines non-invasive physical, cognitive, and cortisol markers to assess frailty in aging adults.</p><p><strong>Methods: </strong>Data were collected from four sites as part of the Healthy Minds for Life (HML) longitudinal cohort, a project within the Precision Aging Network. Baseline data included cognitive evaluation using the Montreal Cognitive Assessment (MoCA); frailty assessment using a validated 20-second elbow flexion-extension test analyzed by AI under single-task and dual-task conditions; cortisol measurement in eccrine sweat samples via Direct Analysis in Real Time Mass Spectrometry (DART-MS); and demographic information.</p><p><strong>Results: </strong>Of 202 participants completing all assessments, 60 were identified with mild cognitive impairment (MCI). The dual-task frailty index (FI) derived from the 20-second test significantly differentiated individuals with MCI from cognitively robust participants and correlated strongly with MoCA scores (p = 0.015). The dual-task FI showed superior model fit compared to the single-task FI when predicting cognitive function. A significant correlation between the dual-task FI and cortisol by age interaction was observed (p = 0.0042) highlighting the potential impact of cortisol to moderate the relationship between frailty and age in an otherwise healthy aging population. By contrast, no significant correlation was found between dual-task FI and aging outside of the presence of cortisol (p = 0.116) in this study.</p><p><strong>Conclusions: </strong>This study highlights practical and efficient methods for assessing frailty emphasizing the value of dual-task testing and cortisol measures in identifying individuals at higher risk for cognitive and physical decline. The findings underscore the importance of integrating hormonal markers with cognitive and physical assessments to enhance risk stratification and intervention planning in aging populations.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":" ","pages":"1-20"},"PeriodicalIF":3.1000,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Decoding Precision Aging: The Intersection of Cognitive Decline, Frailty, and Hormonal Biomarkers.\",\"authors\":\"J Ray Runyon, Mohammad Dehghan Rouzi, Myeounggon Lee, Cole Babbitt, David W Tano, Diezel Cochenour, Esther M Sternberg, Terrill Yuhas, Lisa White, Bijan Najafi, Bonnie J LaFleur\",\"doi\":\"10.1159/000546250\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cognitive frailty, characterized by the coexistence of cognitive impairment and physical frailty, is a significant predictor of cognitive decline. However, few studies integrate both cognitive and physical assessments alongside hormonal markers, such as cortisol, that may influence frailty and cognitive function. To address this gap, our study combines non-invasive physical, cognitive, and cortisol markers to assess frailty in aging adults.</p><p><strong>Methods: </strong>Data were collected from four sites as part of the Healthy Minds for Life (HML) longitudinal cohort, a project within the Precision Aging Network. Baseline data included cognitive evaluation using the Montreal Cognitive Assessment (MoCA); frailty assessment using a validated 20-second elbow flexion-extension test analyzed by AI under single-task and dual-task conditions; cortisol measurement in eccrine sweat samples via Direct Analysis in Real Time Mass Spectrometry (DART-MS); and demographic information.</p><p><strong>Results: </strong>Of 202 participants completing all assessments, 60 were identified with mild cognitive impairment (MCI). The dual-task frailty index (FI) derived from the 20-second test significantly differentiated individuals with MCI from cognitively robust participants and correlated strongly with MoCA scores (p = 0.015). The dual-task FI showed superior model fit compared to the single-task FI when predicting cognitive function. A significant correlation between the dual-task FI and cortisol by age interaction was observed (p = 0.0042) highlighting the potential impact of cortisol to moderate the relationship between frailty and age in an otherwise healthy aging population. By contrast, no significant correlation was found between dual-task FI and aging outside of the presence of cortisol (p = 0.116) in this study.</p><p><strong>Conclusions: </strong>This study highlights practical and efficient methods for assessing frailty emphasizing the value of dual-task testing and cortisol measures in identifying individuals at higher risk for cognitive and physical decline. The findings underscore the importance of integrating hormonal markers with cognitive and physical assessments to enhance risk stratification and intervention planning in aging populations.</p>\",\"PeriodicalId\":12662,\"journal\":{\"name\":\"Gerontology\",\"volume\":\" \",\"pages\":\"1-20\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-05-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gerontology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000546250\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gerontology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000546250","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Decoding Precision Aging: The Intersection of Cognitive Decline, Frailty, and Hormonal Biomarkers.
Background: Cognitive frailty, characterized by the coexistence of cognitive impairment and physical frailty, is a significant predictor of cognitive decline. However, few studies integrate both cognitive and physical assessments alongside hormonal markers, such as cortisol, that may influence frailty and cognitive function. To address this gap, our study combines non-invasive physical, cognitive, and cortisol markers to assess frailty in aging adults.
Methods: Data were collected from four sites as part of the Healthy Minds for Life (HML) longitudinal cohort, a project within the Precision Aging Network. Baseline data included cognitive evaluation using the Montreal Cognitive Assessment (MoCA); frailty assessment using a validated 20-second elbow flexion-extension test analyzed by AI under single-task and dual-task conditions; cortisol measurement in eccrine sweat samples via Direct Analysis in Real Time Mass Spectrometry (DART-MS); and demographic information.
Results: Of 202 participants completing all assessments, 60 were identified with mild cognitive impairment (MCI). The dual-task frailty index (FI) derived from the 20-second test significantly differentiated individuals with MCI from cognitively robust participants and correlated strongly with MoCA scores (p = 0.015). The dual-task FI showed superior model fit compared to the single-task FI when predicting cognitive function. A significant correlation between the dual-task FI and cortisol by age interaction was observed (p = 0.0042) highlighting the potential impact of cortisol to moderate the relationship between frailty and age in an otherwise healthy aging population. By contrast, no significant correlation was found between dual-task FI and aging outside of the presence of cortisol (p = 0.116) in this study.
Conclusions: This study highlights practical and efficient methods for assessing frailty emphasizing the value of dual-task testing and cortisol measures in identifying individuals at higher risk for cognitive and physical decline. The findings underscore the importance of integrating hormonal markers with cognitive and physical assessments to enhance risk stratification and intervention planning in aging populations.
期刊介绍：
In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.
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