{"title":"一个不寻常和有趣的连续严重不良事件的病例。","authors":"Trupti Rekha Swain, Lorika Sahu, Jyotishree Mallik","doi":"10.4103/ijp.ijp_675_22","DOIUrl":null,"url":null,"abstract":"<p><strong>Abstract: </strong>Hydrocortisone and pheniramine are frequently administered drugs for the management of severe allergic or anaphylactic reactions. However, there is hardly any literature that shows the association between the use of these drugs for the management of anaphylactic reactions that can induce serious adverse effect. We present a peculiar case of loss of consciousness following concurrent administration of intravenous pheniramine (Avil) and hydrocortisone (primacort) for the management of another drug-induced adverse reaction characterized by urticaria and pruritis that erupted succeeding intake of a fluoroquinolone group of the drug (ofloxacin). Loss of consciousness associated with pheniramine is a serious adverse drug reaction and its association was found out to be \"probable/likely\" according to the WHO-UMC Causality Assessment Scale. Such reactions, although rare, can be serious requiring immediate hospitalization and warrant vigilance.</p>","PeriodicalId":13490,"journal":{"name":"Indian Journal of Pharmacology","volume":"57 1","pages":"52-54"},"PeriodicalIF":1.4000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"An unusual and interesting case of sequential serious adverse event.\",\"authors\":\"Trupti Rekha Swain, Lorika Sahu, Jyotishree Mallik\",\"doi\":\"10.4103/ijp.ijp_675_22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Abstract: </strong>Hydrocortisone and pheniramine are frequently administered drugs for the management of severe allergic or anaphylactic reactions. However, there is hardly any literature that shows the association between the use of these drugs for the management of anaphylactic reactions that can induce serious adverse effect. We present a peculiar case of loss of consciousness following concurrent administration of intravenous pheniramine (Avil) and hydrocortisone (primacort) for the management of another drug-induced adverse reaction characterized by urticaria and pruritis that erupted succeeding intake of a fluoroquinolone group of the drug (ofloxacin). Loss of consciousness associated with pheniramine is a serious adverse drug reaction and its association was found out to be \\\"probable/likely\\\" according to the WHO-UMC Causality Assessment Scale. Such reactions, although rare, can be serious requiring immediate hospitalization and warrant vigilance.</p>\",\"PeriodicalId\":13490,\"journal\":{\"name\":\"Indian Journal of Pharmacology\",\"volume\":\"57 1\",\"pages\":\"52-54\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Pharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.4103/ijp.ijp_675_22\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/5/6 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Pharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4103/ijp.ijp_675_22","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/6 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
An unusual and interesting case of sequential serious adverse event.
Abstract: Hydrocortisone and pheniramine are frequently administered drugs for the management of severe allergic or anaphylactic reactions. However, there is hardly any literature that shows the association between the use of these drugs for the management of anaphylactic reactions that can induce serious adverse effect. We present a peculiar case of loss of consciousness following concurrent administration of intravenous pheniramine (Avil) and hydrocortisone (primacort) for the management of another drug-induced adverse reaction characterized by urticaria and pruritis that erupted succeeding intake of a fluoroquinolone group of the drug (ofloxacin). Loss of consciousness associated with pheniramine is a serious adverse drug reaction and its association was found out to be "probable/likely" according to the WHO-UMC Causality Assessment Scale. Such reactions, although rare, can be serious requiring immediate hospitalization and warrant vigilance.
期刊介绍:
Indian Journal of Pharmacology accepts, in English, review articles, articles for educational forum, original research articles (full length and short communications), letter to editor, case reports and interesting fillers. Articles concerning all aspects of pharmacology will be considered. Articles of general interest (e.g. methods, therapeutics, medical education, interesting websites, new drug information and commentary on a recent topic) are also welcome.