一个不寻常和有趣的连续严重不良事件的病例。

IF 1.4 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Indian Journal of Pharmacology Pub Date : 2025-01-01 Epub Date: 2025-05-06 DOI:10.4103/ijp.ijp_675_22
Trupti Rekha Swain, Lorika Sahu, Jyotishree Mallik
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引用次数: 0

摘要

摘要:氢化可的松和苯那敏是治疗严重过敏反应的常用药物。然而,几乎没有任何文献显示这些药物用于管理可引起严重不良反应的过敏反应之间的关联。我们提出了一个特殊的情况下,意识丧失后静脉注射苯那敏(阿维尔)和氢化可的松(primacort)管理的另一个药物引起的不良反应,以荨麻疹和瘙痒为特征,爆发后摄入氟喹诺酮类药物组(氧氟沙星)。pheniramine引起的意识丧失是一种严重的药物不良反应,根据WHO-UMC因果关系评估量表,其相关性被认定为“可能/可能”。这种反应虽然罕见,但可能严重到需要立即住院治疗,需要保持警惕。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An unusual and interesting case of sequential serious adverse event.

Abstract: Hydrocortisone and pheniramine are frequently administered drugs for the management of severe allergic or anaphylactic reactions. However, there is hardly any literature that shows the association between the use of these drugs for the management of anaphylactic reactions that can induce serious adverse effect. We present a peculiar case of loss of consciousness following concurrent administration of intravenous pheniramine (Avil) and hydrocortisone (primacort) for the management of another drug-induced adverse reaction characterized by urticaria and pruritis that erupted succeeding intake of a fluoroquinolone group of the drug (ofloxacin). Loss of consciousness associated with pheniramine is a serious adverse drug reaction and its association was found out to be "probable/likely" according to the WHO-UMC Causality Assessment Scale. Such reactions, although rare, can be serious requiring immediate hospitalization and warrant vigilance.

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来源期刊
CiteScore
4.00
自引率
4.20%
发文量
53
审稿时长
4-8 weeks
期刊介绍: Indian Journal of Pharmacology accepts, in English, review articles, articles for educational forum, original research articles (full length and short communications), letter to editor, case reports and interesting fillers. Articles concerning all aspects of pharmacology will be considered. Articles of general interest (e.g. methods, therapeutics, medical education, interesting websites, new drug information and commentary on a recent topic) are also welcome.
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