钝性胸外伤后心肌挫伤的生化指标。

IF 2.2 3区 医学 Q2 EMERGENCY MEDICINE
Makhabbat Bekbossynova, Murat Mukarov, Perizat Kanabekova, Zhanerke Shaktybek, Madina Sugralimova, Arman Batpen, Anar Kozhakhmetova, Zhumagul Sholdanova, Aknur Zhanbolat
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引用次数: 0

摘要

外伤引起的心脏损伤最常见的表现之一是心肌挫伤。今天,模糊的定义和广泛的非特异性临床表现导致缺乏共识的诊断途径和标准。目前临床上检测心脏损伤的标志是肌钙蛋白,仪器诊断工具是心电图。胸外伤后肌钙蛋白水平升高的患者应怀疑有心肌挫伤,可能并发心源性休克或心律失常。创伤后DAMPs的释放已被观察到作为炎症反应的一部分。HMGB1蛋白和组蛋白水平在创伤患者中升高,并与炎症有关。在这篇综述中讨论了这些分子作为心肌挫伤诊断标志物的潜力。此外,还指出了DAMPS在临床应用中存在的障碍和未来的研究方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Biochemical markers of myocardial contusion after blunt chest trauma.

Biochemical markers of myocardial contusion after blunt chest trauma.

Biochemical markers of myocardial contusion after blunt chest trauma.

One of the most common manifestations of cardiac injury because of trauma is myocardial contusion. Today, the blurred definition and wide range of nonspecific clinical presentations led to absence in consensus of diagnostic pathways and criteria. Currently, the marker of cardiac injury measured at clinical level is troponin and instrumental diagnostic tool is ECG. The patients with elevated troponin level after the chest trauma should be suspected to have myocardial contusion as cardiogenic shock or arrhythmia might take place as a complication. The release of DAMPs after the trauma has been observed as a part of inflammatory response to it. HMGB1 protein and histone levels were found to be elevated in patients with trauma and associated to recruit the inflammation. In this review the potential of these molecules to be used as diagnostic markers of myocardial contusion is discussed. Moreover, the obstacles for implementing DAMPS to clinical protocols and future research directions are included.

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来源期刊
CiteScore
4.50
自引率
14.30%
发文量
311
审稿时长
3 months
期刊介绍: The European Journal of Trauma and Emergency Surgery aims to open an interdisciplinary forum that allows for the scientific exchange between basic and clinical science related to pathophysiology, diagnostics and treatment of traumatized patients. The journal covers all aspects of clinical management, operative treatment and related research of traumatic injuries. Clinical and experimental papers on issues relevant for the improvement of trauma care are published. Reviews, original articles, short communications and letters allow the appropriate presentation of major and minor topics.
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