外伤性脑损伤中央丘脑深部脑刺激试验症状的定性分析

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY
NeuroRehabilitation Pub Date : 2025-03-01 Epub Date: 2025-01-21 DOI:10.1177/10538135241296732
Linda M Gerber, Kaiulani S Shulman, Megan S Wright, Nicholas D Schiff, Joseph J Fins
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引用次数: 0

摘要

背景:中重度创伤性脑损伤(TBI)的研究报告了损伤后持续的临床损伤。在CENTURY-S对慢性TBI深部脑刺激(DBS)的研究中,Schiff等人的论文“创伤性脑损伤中的丘脑深部脑刺激:1期随机可行性研究”证明了执行控制的改善。另一篇由Fins等人撰写的叙述者分析,“从创伤性脑损伤的中央丘脑深部脑刺激试验的受试者和家庭视角”,第一部分和第二部分描述了认知、行为和情感能力的改善。目的本研究利用受试者及其家庭成员在dbs前后的叙述,提供一种综合症状评估。方法利用CENTURY-S研究的参与者,Fins等人对5名中度至重度脑外伤患者及其家庭成员进行了半结构化访谈。转录本随后由两名独立调查员在Dedoose中进行演绎和归纳编码。结果受试者及其家属经常自愿在dbs前出现记忆和认知症状以及自我调节困难、沮丧和易怒。在刺激之后,4名受试者和4个家庭在记忆力、注意力和注意力方面都有所改善,而3名受试者和5个家庭自愿在自我调节方面有所改善。先前报告有此症状的三名受试者的疲劳有所改善,另一名未报告此症状。结论对DBS试验参与者叙述数据的二次定性分析支持将定性数据作为TBI中DBS研究的附加结果指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Qualitative Analysis of Symptoms from the Central Thalamic Deep Brain Stimulation Trial for Traumatic Brain Injury.

BackgroundStudies of moderate-to-severe traumatic brain injury (TBI) report persistent clinical impairment post-injury. In the CENTURY-S study of deep brain stimulation (DBS) in chronic TBI, Schiff et al.'s paper, "Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study" demonstrated improvements in executive control. A companion narrative analysis by Fins et al., "Subject and Family Perspectives from the Central Thalamic Deep Brain Stimulation Trial for Traumatic Brain Injury" Parts I and II described improvements in cognitive, behavioral, and emotional capabilities.ObjectiveThe present study provides an aggregate symptom assessment utilizing pre- and post-DBS narratives from subjects and their family members.MethodsDrawing upon participants from the CENTURY-S study, Fins et al. conducted semi-structured interviews with five subjects with moderate-to-severe TBI and their family members. Transcripts were subsequently coded deductively and inductively in Dedoose by two independent investigators.ResultsSubjects and families frequently volunteered memory and cognitive symptoms as well as difficulties with self-regulation, frustration, and irritability pre-DBS. Following stimulation, four subjects and four families noted improvement in memory and attention and focus, while three subjects and five families volunteered improvements in self-regulation. Fatigue improved in three subjects who previously reported this symptom and in one who did not.ConclusionsSecondary qualitative analysis of narrative data of DBS trial participants supports the incorporation of qualitative data as additional outcome measures in studies of DBS in TBI.

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来源期刊
NeuroRehabilitation
NeuroRehabilitation CLINICAL NEUROLOGY-REHABILITATION
CiteScore
3.20
自引率
0.00%
发文量
178
审稿时长
6-12 weeks
期刊介绍: NeuroRehabilitation, an international, interdisciplinary, peer-reviewed journal, publishes manuscripts focused on scientifically based, practical information relevant to all aspects of neurologic rehabilitation. We publish unsolicited papers detailing original work/research that covers the full life span and range of neurological disabilities including stroke, spinal cord injury, traumatic brain injury, neuromuscular disease and other neurological disorders. We also publish thematically organized issues that focus on specific clinical disorders, types of therapy and age groups. Proposals for thematic issues and suggestions for issue editors are welcomed.
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